The Mouse Heart Attack Research Tool 1.0 database

American Journal of Physiology. Heart and Circulatory Physiology
Kristine Y DeLeon-PennellMerry L Lindsey

Abstract

The generation of big data has enabled systems-level dissections into the mechanisms of cardiovascular pathology. Integration of genetic, proteomic, and pathophysiological variables across platforms and laboratories fosters discoveries through multidisciplinary investigations and minimizes unnecessary redundancy in research efforts. The Mouse Heart Attack Research Tool (mHART) consolidates a large data set of over 10 yr of experiments from a single laboratory for cardiovascular investigators to generate novel hypotheses and identify new predictive markers of progressive left ventricular remodeling after myocardial infarction (MI) in mice. We designed the mHART REDCap database using our own data to integrate cardiovascular community participation. We generated physiological, biochemical, cellular, and proteomic outputs from plasma and left ventricles obtained from post-MI and no-MI (naïve) control groups. We included both male and female mice ranging in age from 3 to 36 mo old. After variable collection, data underwent quality assessment for data curation (e.g., eliminate technical errors, check for completeness, remove duplicates, and define terms). Currently, mHART 1.0 contains >888,000 data points and includes results from >2...Continue Reading

References

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Mar 25, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Andriy YabluchanskiyYu-Fang Jin
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Oct 17, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Cesar A MeschiariMerry L Lindsey
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyGerd Heusch
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyMarielle Scherrer-Crosbie
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Heddwen L Brooks, Merry L Lindsey

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Citations

Jul 20, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Daria V IlatovskayaKristine Y DeLeon-Pennell
Feb 23, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Amanda R KaminskiMerry L Lindsey
Mar 21, 2020·Npj Regenerative Medicine·D Kent ArrellAndre Terzic
Aug 23, 2018·Basic Research in Cardiology·Kristine Y DeLeon-PennellMerry L Lindsey
Feb 14, 2021·Npj Regenerative Medicine·D Kent ArrellAndre Terzic
Mar 27, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Alexander J Whitehead, Adam J Engler
Jun 12, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyKeith R Brunt
Oct 2, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Yusra ZaidiKristine Y DeLeon-Pennell
Oct 9, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyZamaneh Kassiri

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Datasets Mentioned

BETA
GM-114833
GM-115428

Methods Mentioned

BETA
PCR
gene array
PCA

Software Mentioned

STATA
SAS
Mouse Heart Attack Research Tool
REDCap
Excel
REDCap Designer
mHART
Online Designer
VisualSonics
Mouse Heart Attack Research Tool ( mHART )

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