The mouse immunoglobulin kappa light-chain genes are located in early- and late-replicating regions of chromosome 6.

Molecular and Cellular Biology
K S Hatton, Carl L Schildkraut

Abstract

The murine immunoglobulin kappa (kappa) light-chain multigene family includes the constant region (C kappa), joining-region genes, and approximately 30 kappa-variable (V kappa) region families. The entire region occupies an estimated 1,000 to 3,000 kilobases, and some V kappa families have been linked by recombinant inbred mapping. The C kappa gene and 14 V kappa families replicated differently among cell lines of lymphoid and nonlymphoid origin. In nonlymphoid cells, the C kappa gene replicated earlier than the V kappa families. A transition from replication during the second third of S phase for the C kappa gene to later replication during S for V kappa families was observed. The V kappa family (V kappa 21) that maps closest to the C kappa gene, replicated during the first half of the S phase; most of the other V kappa families replicated during the second half of S, and some replicated during the last quarter of the S phase. In lymphoid cells, the kappa locus replicated earlier in the pre-B than in the B-cell lines. In one pre-B-cell line, 22D6, the kappa genes examined replicated at the beginning of the S phase. In the B-cell lines, the EcoRI segment containing the transcribed gene replicated near the beginning of the S pha...Continue Reading

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Citations

Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jie ZhouBarbara K Birshtein
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·R S HansenS M Gartler
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·R S HansenS M Gartler
Jan 9, 2008·Journal of Cellular Biochemistry·Sahar SibaniMaria Zannis-Hadjopoulos
Mar 1, 1997·Somatic Cell and Molecular Genetics·P S Subramanian, A C Chinault
Jun 8, 2002·Molecular and Cellular Biology·Jie ZhouCarl L Schildkraut

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