Jan 22, 2003

The mouse MPTP model: gene expression changes in dopaminergic neurons

The European Journal of Neuroscience
Kati KühnChristine C Stichel

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder, characterized by the progressive loss of dopaminergic neurons in the substantia nigra. Although valuable animal models have been developed, our knowledge of the aetiology and pathogenic factors implicated in PD is still insufficient to develop causal therapeutic strategies aimed at halting its progression. The neurotoxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is one of the most valuable models for analysing pathological aspects of PD. In this paper we studied the gene expression patterns underlying the pathogenesis of MPTP-induced neurodegeneration. We treated young and old C57BL/6 mice with different schedules of MPTP to induce degenerative processes that vary in intensity and time-course. During the first week after intoxication we used nonradioactive in situ-hybridization to investigate the expression patterns of genes associated with (i) dopamine metabolism and signalling; (ii) familial forms of PD; (iii) protein folding and (iv) energy metabolism. MPTP injections induced different severities of neuronal injury depending on the age of the animals and the schedule of administration as well as a significant degeneration in the striatum...Continue Reading

Mentioned in this Paper

Alcoholic Intoxication
Heat shock proteins
MPTP-Induced Degeneration of the Striatum
Treatment Protocols
Patterns
Abnormal Degeneration
Pathogenesis
Genes
C57BL/6 Mouse
EPRS

About this Paper

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