The Mouse Solitary Odorant Receptor Gene Promoters as Models for the Study of Odorant Receptor Gene Choice

PloS One
Andrea Degl'InnocentiMeike Teschke

Abstract

In vertebrates, several anatomical regions located within the nasal cavity mediate olfaction. Among these, the main olfactory epithelium detects most conventional odorants. Olfactory sensory neurons, provided with cilia exposed to the air, detect volatile chemicals via an extremely large family of seven-transmembrane chemoreceptors named odorant receptors. Their genes are expressed in a monogenic and monoallelic fashion: a single allele of a single odorant receptor gene is transcribed in a given mature neuron, through a still uncharacterized molecular mechanism known as odorant receptor gene choice. Odorant receptor genes are typically arranged in genomic clusters, but a few are isolated (we call them solitary) from the others within a region broader than 1 Mb upstream and downstream with respect to their transcript's coordinates. The study of clustered genes is problematic, because of redundancy and ambiguities in their regulatory elements: we propose to use the solitary genes as simplified models to understand odorant receptor gene choice. Here we define number and identity of the solitary genes in the mouse genome (C57BL/6J), and assess the conservation of the solitary status in some mammalian orthologs. Furthermore, we loca...Continue Reading

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Citations

Sep 16, 2019·BMC Bioinformatics·Andrea Degl'InnocentiGianni Ciofani
Mar 9, 2017·Frontiers in Genetics·Andrea Degl'Innocenti, Anna D'Errico
Sep 20, 2018·Nature Communications·Jérémy ChéretRalf Paus

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Methods Mentioned

BETA
fluorescence-activated cell sorting
fluorescence-activated cell sorter
PCR
electrophoresis
RNA-Seq

Software Mentioned

Galaxy
FIMO
MEME Suite
BioMart
JSAN Desktop Cell Sorter
BWA
Idiographica
Ensembl
Inparanoid
BEDTools

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