PMID: 7029264May 1, 1981Paper

The mouse specific-locus test with agents other than radiations: interpretation of data and recommendations for future work

Mutation Research
L B RussellL Valcovic

Abstract

The mouse specific-locus test with visible markers (SLT) has been the only extensively used method for detecting and quantifying the induction of heritable point mutations (intragenic changes and small deficiencies) in mammals. Mutations are detected in first-generation offspring; and scoring is simple, objective, and rapid. Different germ-cell stages can be sampled, including those of greatest pertinence for genetic risk assessment. The differential probability of involving the various loci of the marked set makes the method capable of detecting qualitative (as well as quantitative) differences between the actions of mutagens. Control SLT frequencies for males reported by 4 sets of investigators are in excellent agreement and were summed as a "historical control" (801406 observations) for use in our calculations. Experimental results were classified as positive, negative, or inconclusive based upon a multiple-decision procedure produced by the testing of the following 2 hypotheses: (1) the mutation frequency (induced + spontaneous) of treated mice is not higher than the spontaneous mutation frequency, and (2) the induced mutation frequency of treated mice is no less than 4 times the historical-control mutation frequency. Each ...Continue Reading

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Citations

Jan 1, 1987·Mutation Research·L B Russell, P R Hunsicker
Sep 1, 1988·Mutation Research·I QuintoN Staiano
May 1, 1989·Mutation Research·H V Malling, J G Burkhart
Aug 17, 1996·Mutation Research·K L Witt, J B Bishop
Sep 1, 1985·Mutation Research·L B Russell, M D Shelby
Apr 1, 1988·Mutation Research·K S Bentley, P K Working
Nov 1, 1988·Mutation Research·U H EhlingA Neuhäuser-Klaus
Oct 1, 1989·Mutation Research·U H Ehling, A Neuhäuser-Klaus
Mar 13, 2014·Journal of Applied Genetics·Karolina SłoczyńskaAnna M Waszkielewicz
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L B RussellM D Shelby
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·L B Russell, W L Russell
Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·S E Lewis
Mar 1, 1988·Risk Analysis : an Official Publication of the Society for Risk Analysis·U H Ehling
Jan 1, 1984·Environmental Mutagenesis·H S RosenkranzY Y Haimes
Jan 1, 1985·Environmental Mutagenesis·J M MasonS Zimmering
Jan 1, 1985·Environmental Mutagenesis·J A Skare, K R Schrotel
Aug 30, 2008·Mutation Research·Paul J Donovan, George T Smith

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