The MRN complex in double-strand break repair and telomere maintenance.

FEBS Letters
Brandon J LamarcheMatthew D Weitzman

Abstract

Genomes are subject to constant threat by damaging agents that generate DNA double-strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA damage recognition and end-joining, and this is achieved through protein-DNA complexes known as telomeres. The Mre11-Rad50-Nbs1 (MRN) complex plays important roles in detection and signaling of DSBs, as well as the repair pathways of homologous recombination (HR) and non-homologous end-joining (NHEJ). In addition, MRN associates with telomeres and contributes to their maintenance. Here, we provide an overview of MRN functions at DSBs, and examine its roles in telomere maintenance and dysfunction.

References

Jan 1, 1995·Advances in Biophysics·H OgawaA H Hagihara
Jul 1, 1997·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·K M Kironmai, K Muniyappa
Apr 16, 1998·The Journal of Biological Chemistry·E P RogakouW M Bonner
Aug 15, 1998·The Journal of Biological Chemistry·K M TrujilloP Sung
Feb 26, 1999·Science·J KarlsederT de Lange
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·G LuoJ H Petrini
Dec 13, 2000·Molecular and Cellular Biology·O K Mirzoeva, J H Petrini
Mar 10, 2001·Molecular and Cellular Biology·A Desai-MehtaP Concannon
Dec 14, 2001·Molecular Cell·M de JagerC Wyman
Apr 23, 2002·Current Biology : CB·Bret R WilliamsJohn H J Petrini
May 4, 2002·Nature Reviews. Molecular Cell Biology·Damien D'Amours, Stephen P Jackson
Jul 19, 2002·Nature·Travis H StrackerMatthew D Weitzman
Sep 5, 2002·Genes & Development·Carla F BenderJohn H J Petrini
Jan 31, 2003·Nature·Christopher J Bakkenist, Michael B Kastan
Aug 30, 2003·Trends in Cell Biology·John H J Petrini, Travis H Stracker
Sep 6, 2003·Current Biology : CB·Hiroyuki TakaiTitia de Lange

❮ Previous
Next ❯

Citations

Jan 22, 2011·Nature Reviews. Molecular Cell Biology·Travis H Stracker, John H J Petrini
Sep 6, 2011·Nature Structural & Molecular Biology·Marcel HohlJohn H J Petrini
Nov 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jung-Hyun KimNatalay Kouprina
Jan 3, 2012·Nucleic Acids Research·Yasuko KamisugiFabien Nogué
Aug 5, 2011·Current Opinion in Urology·Yuanbin RuDan Theodorescu
Jan 11, 2012·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Simone PellegrinoJoanna Timmins
Dec 3, 2010·Journal of Virology·Nicole I OrazioMatthew D Weitzman
Nov 28, 2012·Genome Integrity·Inger Brandsma, Dik C Gent
Jun 14, 2014·PloS One·Romana KoppensteinerKonstantin J Dedes
Aug 7, 2013·Journal of Biochemistry·Naoyuki HayashiKen-ichi Yamamoto
Feb 14, 2012·Future Microbiology·Sabrina SchreinerThomas Dobner
Aug 28, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ya-Zhou HeZi-Qiang Wang
Jul 16, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Shauna M McKelveyRichard A Murphy
May 10, 2011·FEBS Letters·Matthew D WeitzmanMira S Chaurushiya
Feb 18, 2015·International Journal of Molecular Sciences·Chun-Yuan ChangYi-Jang Lee
Oct 8, 2015·Annual Review of Physiology·Anna UrygaMartin Bennett
Sep 7, 2011·DNA Repair·Claire WymanRoland Kanaar
Mar 6, 2016·Trends in Endocrinology and Metabolism : TEM·Matthew J Schiewer, Karen E Knudsen
Jan 2, 2016·Pharmacological Reports : PR·Tae-Won KimJu-Young Jung
Nov 28, 2015·Blood·Marco Colonna
Nov 2, 2012·International Journal of Cancer. Journal International Du Cancer·Laura ConradtGünter Schneider
Jan 26, 2011·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Ludger KlewesSabine Mai
Jun 24, 2011·IUBMB Life·Alessandra di MasiPaolo Ascenzi
Sep 10, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Edward C Gilmore, Christopher A Walsh
Oct 12, 2013·International Journal of Cancer. Journal International Du Cancer·Zhan ZhangShou-Lin Wang
Feb 11, 2014·International Journal of Cancer. Journal International Du Cancer·Katharina GruppAlexander Quaas
Mar 26, 2016·Seminars in Cell & Developmental Biology·Zhouliang YuAbby F Dernburg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.