The mRNA expressions and immunohistochemistry of factors involved in angiogenesis and lymphangiogenesis in the early stage of rat skin incision wounds

Legal Medicine
Hiroshi KameyamaMakoto Nogami

Abstract

Wound healing evaluation is important in forensic pathology, in which angiogenesis plays an important role. We have already shown that vascular endothelial growth factor A (VEGF) is produced in the rat skin incision wounds by neutrophils, endothelial cells, and fibroblasts. In this study, we assessed the changes in the mRNA expressions of various factors possibly involved in angiogenesis including angiopoietin (ANGPT) 1 and 2, cadherin 5 (CDH5), granulocyte-macrophage colony stimulating factor (CSF2/GM-CSF), granulocyte colony stimulating factor (CSF3/G-CSF), chemokine (C-X-C motif) ligand 2 (CXCL2), chemokine (C-X-C motif) ligand12 (CXCL12/SDF1), endothelin 1 (ET1), fibroblast growth factor 1 (FGF 1), hepatocyte growth factor (HGF), hypoxia inducible factor 1 alpha (HIF1a), leptin, matrix metallopepitidase 9 (MMP9), serpine/plasminogen activator inhibitor1 (PAI1), platelet-derived growth factor-A (PDGF-A), transforming growth factor alpha and beta 1 (TGFa and b1), tenomodulin (TNMD), and troponin I type 2 (TNNI2) in the early stage of the rat skin incision wounds by real time RT-PCR. Factors reported to be involved in lymphangiogenesis such as fibroblast growth factor 2 (FGF 2), c-fos induced growth factor (FIGF/VEGF-D), forkh...Continue Reading

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S WernerL T Williams
Mar 1, 1991·The Journal of Clinical Investigation·F BussolinoA Mantovani
Jan 1, 1991·Pharmacology & Therapeutics·C SunderkötterC Sorg
Apr 1, 1998·Journal of the National Cancer Institute·J YonedaI J Fidler
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·M A MosesR Langer
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·L MarconciniS Oliviero
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 3, 2002·The EMBO Journal·Jeffrey T WigleGuillermo Oliver
May 25, 2002·The British Journal of Surgery·J C S TsuiM R Dashwood
May 29, 2002·Molecular Pathology : MP·Q H SongV Trinkaus-Randall
Dec 25, 2002·Microscopy Research and Technique·Jie LiRobert S Kirsner
Feb 20, 2003·The Journal of Surgical Research·Jason P ShawPeter Shamamian
Aug 19, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ali MuradM Rocío Sierra-Honigmann
Jun 8, 2004·Current Gene Therapy·Ryuichi MorishitaToshio Ogihara
Apr 28, 2005·Journal of Cell Science·Christina H StueltenAnita B Roberts
Jul 12, 2005·Trends in Cell Biology·Tuomas TammelaKari Alitalo
Aug 17, 2005·Current Drug Targets. Inflammation and Allergy·Tsuyoshi KasamaSteven L Kunkel
Oct 7, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·A V BeloS P Andrade
Oct 15, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuichi OhkiAkimichi Ohsaka
Jul 1, 2006·Lymphatic Research and Biology·Rui-Cheng Ji
Jun 19, 2007·Medical Molecular Morphology·Makoto NogamiIchiro Takahashi
Jul 14, 2007·Current Pharmaceutical Design·Chisa Shukunami, Yuji Hiraki
Apr 1, 2008·Acta Cirúrgica Brasileira·Ioannis LiapakiConstantinos Simopoulos
Mar 21, 2009·Blood·Dirk HoseThomas Möhler
Jul 11, 2009·The American Journal of Pathology·Noriko HattoriYasunori Okada
Jul 17, 2010·The British Journal of Dermatology·C A StatonN J Brown
May 25, 2011·The Journal of Clinical Investigation·Marie JeanssonSusan E Quaggin
Jul 25, 2012·Journal of the American Podiatric Medical Association·Xiao-Ying XieLi Yan
Sep 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Renhai CaoYihai Cao
Apr 5, 2013·BioMed Research International·Victor W Wong, Jeffrey D Crawford

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Citations

Apr 30, 2015·International Journal of Pediatric Otorhinolaryngology·Maria MakuszewskaMaria Małgorzata Winnicka
May 29, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Juliana M GuerraLeonardo J T de Araújo
Jan 13, 2019·Journal of Translational Medicine·Dominic HennVolker J Schmidt
Nov 30, 2016·Oncology Letters·Anna Agnieszka Klimczak-BitnerJanusz Szemraj

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