PMID: 9160344Feb 1, 1997Paper

The MS Impairment Scale: a pragmatic approach to the assessment of impairment in patients with multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
M RavnborgA Jønsson

Abstract

We developed a measurement scale for assessment of impairment in MS patients (MSIS) in accordance with the recommendations of WHO. The items were kept close to a standard neurologic examination, and a short battery of cognitive tests was added. Normality was assigned to the value, zero, and the theoretical maximum score was 204. Two-hundred and ten multiple sclerosis (MS) patients were rated by one neurologist on the MS impairment Scale (MSIS), the Extended Disability Status Scale (EDSS), and the Ambulation Index (AI). The median MSIS score was 52 (5-147), the median EDSS 6.5 (1-9.5), and the median AI 5 (1-5). The relation between the MSIS scores and the EDSS was best described by an exponential function (non-linear regression coefficient, R = 0.87). Sixty-two of the patients were reexamined and rated by another neurologist. The interrater reliability coefficient (R) of the MSIS was 0.95, of the EDSS 0.91, and of the AI 0.94. Forty patients were examined twice by the first neurologist. The intrarater reliability coefficient was 0.97 for the MSIS, 0.95 for the EDSS, and 0.98 for the AI. The MSIS is easy to use and is robust to observer dissimilarities. It has a monomodal univariate distribution and has a better discriminatory p...Continue Reading

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Citations

Oct 31, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Kostas KonstantopoulosDimos-Dimitrios Mitsikostas
Jun 18, 2005·Journal of the Neurological Sciences·L M JørgensenM Ravnborg
Sep 15, 2014·Journal of Neuroimmunology·R RatzerF Sellebjerg
Oct 12, 2010·Disability and Rehabilitation·Olga SvestkovaAlberto Raggi
Sep 27, 2008·Journal of the Neurological Sciences·M D'SouzaA Czaplinski
Mar 23, 2007·Journal of the Neurological Sciences·Maria Pia Amato, Emilio Portaccio
Mar 31, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Henrik Kahr MathiesenLars G Hanson
Dec 11, 2008·Human Brain Mapping·Sarlota MesarosMassimo Filippi
Jun 2, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K H ScheuerJ E Nielsen
Aug 30, 2008·Psychology and Psychotherapy·R F BrownJ D Pollard
May 2, 2006·Journal of the Neurological Sciences·Agnete JønssonMads Ravnborg
Dec 29, 2013·NeuroImage. Clinical·Anne-Marie DogonowskiHartwig Roman Siebner
Oct 4, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Rikke RatzerFinn Sellebjerg
Jun 10, 2010·Clinical Neuroradiology·E HattingenS Weidauer
Feb 9, 2017·PloS One·Yaejin MoonJacob J Sosnoff
Mar 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·M RavnborgP Soelberg Sørensen
Aug 12, 2006·Multiple Sclerosis : Clinical and Laboratory Research·M M NieuwenhuisM Ravnborg
Apr 25, 2006·Multiple Sclerosis : Clinical and Laboratory Research·L K StorrM Ravnborg
Aug 12, 2006·Multiple Sclerosis : Clinical and Laboratory Research·R F BrownJ D Pollard
Jan 11, 2019·Frontiers in Neurology·Brian TrummerCraig Blackstone
Feb 7, 2019·Frontiers in Neurology·Marta BellofattoFilippo M Santorelli
Nov 21, 2021·Acta Neurologica Scandinavica·Asta TheodorsdottirMads Henrik Ravnborg

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