Feb 9, 2010

The mtDNA composition of Uzbekistan: a microcosm of Central Asian patterns

International Journal of Legal Medicine
Jodi A IrwinThomas J Parsons

Abstract

In order to better characterize and understand the mtDNA population genetics of Central Asia, the mtDNA control regions of over 1,500 individuals from Uzbekistan have been sequenced. Although all samples were obtained from individuals residing in Uzbekistan, individuals with direct ancestry from neighboring Central Asian countries are included. Individuals of Uzbek ancestry represent five distinct geographic regions of Uzbekistan: Fergana, Karakalpakstan, Khorezm, Qashkadarya, and Tashkent. Individuals with direct ancestry in nearby countries originate from Kazakhstan, Kyrgyzstan, Russia, Afghanistan, Turkmenistan, and Tajikistan. Our data reinforce the evidence of distinct clinal patterns that have been described among Central Asian populations with classical, mtDNA, and Y-chromosomal markers. Our data also reveal hallmarks of recent demographic events. Despite their current close geographic proximity, the populations with ancestry in neighboring countries show little sign of admixture and retain the primary mtDNA patterns of their source populations. The genetic distances and haplogroup distributions among the ethnic populations are more indicative of a broad east-west cline among their source populations than of their relati...Continue Reading

  • References22
  • Citations23

References

  • References22
  • Citations23

Citations

Mentioned in this Paper

DNA, Mitochondrial
Genetics, Population
Ethnic Group
Chromosomes
Clinitrachus argentatus
Genetic Fingerprinting
Mitochondrial DNA Location
Single Nucleotide Polymorphism
Nested Polymerase Chain Reaction

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