The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels

Molecular Genetics and Metabolism
Anne Parle-McDermottJohn M Scott

Abstract

Individuals homozygous for the thermolabile variant (677TT) of methylenetetrahydrofolate reductase exhibit reduced folate status as evidenced by a drop in the biomarker red cell folate (RCF) compared to those who carry at least one 677C allele. We now report that a different polymorphism in the same enzyme, namely 1298A>C, is associated with increased RCF levels. Thus, these two common polymorphisms change a metabolic phenotype in opposite directions suggesting that their cancer protective associations are by different mechanisms.

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Citations

Feb 23, 2012·Journal of Nutrigenetics and Nutrigenomics·Patrick J Stover
Jun 18, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shu-Zhe XieJiang-Bo Qin
Jun 19, 2007·Fertility and Sterility·Mitchell P RosenAnthony T Dobson
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Jul 29, 2020·Maternal & Child Nutrition·Tanja Jankovic-KarasoulosClaire T Roberts
Oct 25, 2017·Indian Journal of Clinical Biochemistry : IJCB·Upendra YadavVandana Rai
Feb 24, 2018·PloS One·Shirisha ChittiboyinaBarbara A Hocevar
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rohini SharmaStephen J Clarke

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