The mTORC1-autophagy pathway is a target for senescent cell elimination

Biogerontology
Olena KucheryavenkoBernadette Carroll

Abstract

Cellular senescence has recently been established as a key driver of organismal ageing. The state of senescence is controlled by extensive rewiring of signalling pathways, at the heart of which lies the mammalian Target of Rapamycin Complex I (mTORC1). Here we discuss recent publications aiming to establish the mechanisms by which mTORC1 drives the senescence program. In particular, we highlight our data indicating that mTORC1 can be used as a target for senescence cell elimination in vitro. Suppression of mTORC1 is known to extend lifespan of yeast, worms, flies and some mouse models and our proof-of-concept experiments suggest that it can also act by reducing senescent cell load in vivo.

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Citations

Apr 3, 2020·Cancers·Tareq SalehDavid A Gewirtz
Jun 4, 2020·Biogerontology·Viktor I Korolchuk, Katarzyna Goljanek-Whysall
Aug 8, 2020·Klinicheskaia laboratornaia diagnostika·A V LugovayaA V Artemova
May 20, 2019·Biogerontology·Lynne Cox, Katarzyna Goljanek-Whysall
Feb 15, 2020·Canadian Journal of Physiology and Pharmacology·Guiqin HouZhaoming Lu
Nov 3, 2020·The FEBS Journal·Harvey E Johnston, Rahul S Samant
Dec 2, 2020·Cells·Constanze MittermeierSusanne Muehlich
Dec 5, 2020·Pharmacology & Therapeutics·Ibrahim Y AbdelgawadBeshay N Zordoky

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