The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation

The European Respiratory Journal
Anna ErmundGunnar C Hansson

Abstract

The beneficial effect of anticholinergic therapy for chronic lung diseases such as chronic obstructive pulmonary disease (COPD) is well documented, although cholinergic stimulation paradoxically inhibits liquid absorption, increases ciliary beat frequency and increases airway surface liquid transport.Using pig tracheobronchial explants, we quantified basal mucus transport before as well as after incubation with the clinically used antimuscarinic compound ipratropium bromide (Atrovent) and stimulation with acetylcholine.As expected, surface liquid transport was increased by acetylcholine and carbachol. In contrast, the mucus bundles secreted from the submucosal glands normally transported on the cilia were stopped from moving by acetylcholine, an effect inhibited by ipratropium bromide. Interestingly, in pigs lacking a functional cystic fibrosis (CF) transmembrane conductance regulator (CFTR) channel, the mucus bundles were almost immobile. As in wild-type pigs, CF surface liquid transport increased after carbachol stimulation. The stagnant CF mucus bundles were trapped on the tracheal surface attached to the surface goblet cells. Pseudomonas aeruginosa bacteria were moved by the mucus bundles in wild-type but not CF pigs.Acetyl...Continue Reading

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Citations

Nov 16, 2018·Annals of the American Thoracic Society·Yuliang XieDavid A Stoltz
Sep 1, 2018·The European Respiratory Journal·Susan Birket
Jul 28, 2019·American Journal of Respiratory Cell and Molecular Biology·Judith A Voynow, Shuo Zheng
Nov 2, 2019·The European Respiratory Journal·Vivian Y LinSteven M Rowe
Apr 4, 2020·Annual Review of Biochemistry·Gunnar C Hansson
Sep 3, 2020·Pathogens and Disease·Merna OshalimBodil Jönsson
Apr 10, 2019·Journal of Internal Medicine·G C Hansson
Mar 12, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yan Shin J LiaoLeah R Reznikov
Aug 1, 2020·Frontiers in Pharmacology·Judith A VoynowApparao B Kummarapurugu
Sep 17, 2019·The Journal of Clinical Investigation·Susan E Birket, Steven M Rowe
Apr 5, 2019·Science Translational Medicine·Charles R EstherRichard C Boucher
Apr 30, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dalia FakihGunnar C Hansson
Apr 19, 2019·JCI Insight·Courtney M Fernandez-PettySteven M Rowe
Oct 8, 2020·ELife·Lynda S OstedgaardMichael J Welsh
Nov 25, 2020·Proceedings of the National Academy of Sciences of the United States of America·Vicky SenderBirgitta Henriques-Normark
Aug 28, 2021·Biomolecules·Judith A Voynow, Meagan Shinbashi
Jun 26, 2021·American Journal of Respiratory and Critical Care Medicine·Drake C BouzekDavid A Stoltz
Nov 27, 2021·Respiratory Research·Anna ErmundGunnar C Hansson

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