PMID: 25725247Mar 1, 2015Paper

The multideterminant model of renal disease in a remote Australian Aboriginal population in the context of early life risk factors: lower birth weight, childhood post-streptococcal glomerulonephritis, and current body mass index influence levels of albumi

Clinical Nephrology
Wendy E HoyDavid A McCredie

Abstract

Australian Aborigines in remote areas have very high rates of kidney disease, which is marked by albuminuria. We describe a "multihit" model of albuminuria in young adults in one remote Aboriginal community. Urinary albumin/creatinine ratios (ACR) were measured in all subjects who volunteered to participate in a community-wide health screen. Subjects for this study were young adults who had birth weights recorded and whose medical records were inspected for a history of post-streptococcal glomerulonephritis (PSGN). Urine ACR levels were evaluated in the context of birth weights, PSGN history and current BMI. 580 subjects (335 males and 245 females) who were aged 18 - 39 years at time of screening and qualified for inclusion. 26% of subjects had birth weights of < 2.5 kg, and the median birth weight was 2.8 kg. 23% of subjects had a remote history of PSGN, all 3 or more years earlier. Median BMI for the group was 21 kg/m2. Urine ACR levels exceeded the microalbuminuria threshold of 3.4 g/mol in 35.5% of subjects. Birth weight (inversely), remote PSGN, and current BMI were all independent predictors of ACR levels. Median levels of ACR were lowest in those with birth weights ≥ 2.5 kg, and no history of PSGN, intermediate in those ...Continue Reading

Citations

Oct 13, 2018·Journal of Paediatrics and Child Health·Alison M VogelWilliam Wong
Oct 7, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Valerie A Luyckx, Barry M Brenner
Jan 23, 2021·International Journal of Molecular Sciences·Takashi Oda, Nobuyuki Yoshizawa
Jul 31, 2021·The Lancet Regional Health. Western Pacific·George TaiaroaSusan Jack

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