The multifaceted impact of pneumococcal conjugate vaccine implementation in children in France between 2001 to 2014

Human Vaccines & Immunotherapeutics
Robert CohenCorinne Levy

Abstract

In 2003, France was the first European country to recommend 7-valent pneumococcal conjugate vaccine (PCV7) for a large proportion of healthy children. With complicated recommendations, the vaccine coverage during the first 4 y of implementation was low, then progressively increased to reach 90% in 2008. The aim of this review was to describe the particular impact of PCVs in a country where the vaccine coverage was initially suboptimal. After PCV7 implementation, the PCV7 serotypes nearly disappeared among pneumococci isolated from meningitis (-73%), other invasive pneumococcal disease (IPD; -90%) and pneumococcal carriage (-97%). Consequently, the rates of penicillin-resistant strains declined. However, because of important serotype replacement, the global effect on the incidence of meningitis (-31%) or other IPD (-14%) was modest and observed only in young children < 2 y old. After PCV13 transition, with immediate high vaccine coverage, the vaccine had an important impact on all pneumococcal disease: reduction of -20% for pneumococcal meningitis, -36% for non-meningitis IPD, -32% for community acquired pneumonia and -15% for S. pneumoniae carriage. These findings underline the complexity of pneumococcal epidemiology and the im...Continue Reading

References

Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W P HausdorffG R Siber
May 2, 2003·The New England Journal of Medicine·Cynthia G WhitneyUNKNOWN Active Bacterial Core Surveillance of the Emerging Infections Program Network
Sep 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Edouard BingenUNKNOWN Bacterial Meningitis Study Group
Jun 16, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R CohenE Bingen
Jul 13, 2006·JAMA : the Journal of the American Medical Association·Luanne Hall-StoodleyJoseph E Kerschner
Sep 3, 2008·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·A LepoutreDaniel Lévy-Bruhl
Nov 22, 2008·The Lancet Infectious Diseases·Ron Dagan, Keith P Klugman
Aug 24, 2010·Diagnostic Microbiology and Infectious Disease·Damien DupontEdouard Bingen
Feb 8, 2011·The Pediatric Infectious Disease Journal·Corinne LevyUNKNOWN Bacterial Meningitis Study Group
Apr 20, 2011·BMC Infectious Diseases·Robert CohenEmmanuelle Varon
Feb 15, 2012·Vaccine·Jae-Hoon SongBernard Fritzell
Feb 15, 2012·The Pediatric Infectious Disease Journal·Robert CohenEmmanuelle Varon
Aug 29, 2012·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·R CohenE Varon
Feb 18, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F AngoulvantR Cohen
Mar 8, 2014·PloS One·Claire JanoirUNKNOWN Observatoires Régionaux du Pneumocoque (ORP) network
Feb 1, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M KempfP Lanotte
Jul 8, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Wouter A A de Steenhuijsen PitersDebby Bogaert
Aug 19, 2015·Lancet·Elena PrinaAntoni Torres

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Citations

Aug 9, 2016·Diagnostic Microbiology and Infectious Disease·Karen M MiernykKaren M Rudolph
Jul 28, 2016·Human Vaccines & Immunotherapeutics·Lijoy VargheseBernard Hoet
Aug 5, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M KillianE Botelho-Nevers
Jun 14, 2019·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Audrey VincentMichael Levy
Mar 24, 2017·FEMS Microbiology Reviews·Diarmaid Hughes, Dan I Andersson
Jun 8, 2021·The Pediatric Infectious Disease Journal·Emilie CoronasUNKNOWN Hospital Network for Evaluating the Management of Common Childhood Diseases

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