The multifaceted role of the renal mononuclear phagocyte system

Cellular Immunology
Susanne F ViehmannSebastian Brähler

Abstract

The kidney contains a large and complex network of mononuclear phagocytes, which includes dendritic cells (DCs) and macrophages (MØs). The distinction between these cell types is traditionally based on the expression of molecular markers and morphology. However, several classification systems are used in parallel to identify DCs and MØs, leading to considerable uncertainty about their identity and functional roles. The discovery that a substantial proportion of macrophages in tissues like the kidney are embryonically derived further complicates the situation. Recent studies have used newly identified transcription factors such as ZBTB46 and lineage tracing techniques for classifying mononuclear phagocytes. These approaches have shed new light on the functional specialization of these cells in health and disease, uncovered an influence of the renal microenvironment and revealed considerable cellular plasticity, especially in inflammatory situations. In this review, the current knowledge about the developmental origins and versatile functional roles of DCs and MØs in kidney homeostasis and disease is discussed.

Citations

Jan 18, 2020·Journal of the American Society of Nephrology : JASN·Alexander M C BöhnerChristian Kurts
Jul 12, 2019·Frontiers in Immunology·Geanncarlo Lugo-VillarinoLuciana Balboa
Apr 23, 2020·International Journal of Molecular Sciences·Priscila Calle, Georgina Hotter
Jan 30, 2019·Nature Reviews. Nephrology·Patrick Ming-Kuen TangHui-Yao Lan
Apr 16, 2019·Frontiers in Immunology·Patrick NeubertJonathan Jantsch
Jan 11, 2019·Bulletin of Experimental Biology and Medicine·V A ShkurupyA M Shestopalov
Oct 12, 2020·Cytokine·Chandan Raybarman, Surajit Bhattacharjee
Aug 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shun WuGui-Lian Xu
Aug 24, 2021·Frontiers in Physiology·Xiaoling WangGuoping Zheng
Sep 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Natallia SaleiBarbara U Schraml
Oct 3, 2021·Journal of the American Society of Nephrology : JASN·Alexander M C BöhnerChristian Kurts

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