The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions

International Journal of Molecular Sciences
Po-Yuan Ke

Abstract

Autophagy is an evolutionarily conserved cellular process in which intracellular components are eliminated via lysosomal degradation to supply nutrients for organelle biogenesis and metabolic homeostasis. Flavivirus infections underlie multiple human diseases and thus exert an immense burden on public health worldwide. Mounting evidence indicates that host autophagy is subverted to modulate the life cycles of flaviviruses, such as hepatitis C virus, dengue virus, Japanese encephalitis virus, West Nile virus and Zika virus. The diverse interplay between autophagy and flavivirus infection not only regulates viral growth in host cells but also counteracts host stress responses induced by viral infection. In this review, we summarize the current knowledge on the role of autophagy in the flavivirus life cycle. We also discuss the impacts of virus-induced autophagy on the pathogeneses of flavivirus-associated diseases and the potential use of autophagy as a therapeutic target for curing flavivirus infections and related human diseases.

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Sep 19, 2018·Nature Cell Biology·Johnna Doherty, Eric H Baehrecke
Sep 29, 2018·Annual Review of Virology·Olga A Maximova, Alexander G Pletnev
Oct 12, 2018·Emerging Microbes & Infections·Naoko Uno, Ted M Ross
Oct 13, 2018·The Journal of General Virology·Hiroyuki MoriYoshiharu Matsuura
Oct 26, 2018·Circulation Research·Mahmoud AbdellatifGuido Kroemer
Oct 26, 2018·Seminars in Liver Disease·Bilon KhambuXiao-Ming Yin

Citations

Aug 28, 2019·Virulence·Brooke LiangIndira U Mysorekar
Mar 4, 2020·Pathology Oncology Research : POR·Tímea SzekerczésKlára Werling
Mar 3, 2019·International Journal of Molecular Sciences·Rossella GrattonSergio Crovella
Oct 28, 2019·Viruses·Taryn M Serman, Michaela U Gack
Apr 28, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Adeyemi A Olanrewaju, Ramin M Hakami
May 1, 2020·Frontiers in Cellular and Infection Microbiology·Zhiqiang HuRenyong Jia
Aug 15, 2020·Frontiers in Microbiology·Quanshi LinPing Zhang
Dec 17, 2019·Therapeutic Delivery·Katherine E Redd BowmanCarol S Lim
Dec 19, 2020·Cell·H-Heinrich HoffmannCharles M Rice
Oct 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcella BassettoAndrea Brancale
Apr 10, 2020·Mechanisms of Ageing and Development·Alica Schöller-MannJörg Bergemann

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