The multifaceted roles of perlecan in fibrosis

Matrix Biology : Journal of the International Society for Matrix Biology
Megan S LordJohn M Whitelock

Abstract

Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a temporal and dynamic fashion. In this review, its roles in fibrosis are reviewed by drawing upon evidence from tissue and organ systems that undergo fibrosis as a result of an uncontrolled response to either inflammation or traumatic cellular injury leading to an over production of a collagen-rich extracellular matrix. This review focuses on examples of fibrosis that occurs in lung, liver, kidney, skin, kidney, neural tissues and blood vessels and its link to the expression of perlecan in that particular organ system.

Citations

Oct 28, 2019·Biochemical Society Transactions·Maurizio MongiatRenato V Iozzo
Mar 19, 2019·Journal of Proteome Research·Sandi G DempseyBarnaby C H May
Aug 27, 2021·Nature·Dimitrios TsiantoulasChristoph J Binder
Dec 17, 2021·Biological Reviews of the Cambridge Philosophical Society·Anne-France de BengyBérengère Fromy

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