The multifactorial nature of microRNAs in vascular remodelling

Cardiovascular Research
Sabine M J WeltenA Yaël Nossent

Abstract

Vascular remodelling is a multifactorial process which involves both adaptive and maladaptive changes of the vessel wall through amongst others, cell proliferation and migration, but also apoptosis and necrosis of the various cell types in the vessel wall. Vascular remodelling can be beneficial e.g. during neovascularization after ischemia, as well as pathological e.g. during atherosclerosis and aneurysm formation. In recent years, it has become clear that microRNAs are able to target many genes that are involved in vascular remodelling processes and either can promote or inhibit structural changes of the vessel wall. Since many different processes of vascular remodelling are regulated by similar mechanisms and factors, both positive and negative vascular remodelling can be affected by the same microRNAs.A large number of microRNAs has been linked to various aspects of vascular remodelling and indeed, several of these microRNAs regulate multiple vascular remodelling processes, including both the adaptive processes angiogenesis and arteriogenesis as well as maladaptive processes of atherosclerosis, restenosis and aneurysm formation. Here, we discuss the multifactorial role of microRNAs and microRNA clusters that were reported to...Continue Reading

References

May 19, 1994·The New England Journal of Medicine·G H Gibbons, V J Dzau
Jul 3, 2004·Clinical Science·Victoria E A Stoneman, Martin R Bennett
Jun 1, 2006·Nature Genetics·Nikolaus Rajewsky
Aug 1, 2006·Nature Genetics·Michael DewsAndrei Thomas-Tikhonenko
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ryan M O'ConnellDavid Baltimore
Jun 2, 2007·Circulation Research·Angelika KuehbacherStefanie Dimmeler
Jan 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tamia A HarrisCharles J Lowenstein
Apr 3, 2008·Arthritis and Rheumatism·Joanna StanczykDiego Kyburz
May 17, 2008·Biochemical Society Transactions·Martin Turner, Elena Vigorito
Aug 13, 2008·Developmental Cell·Shusheng WangEric N Olson
Aug 13, 2008·Developmental Cell·Jason E FishDeepak Srivastava
Jan 6, 2009·Journal of Cellular and Molecular Medicine·Coen van SolingenAnton Jan van Zonneveld
Feb 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Maurizio CeppiPhilippe Pierre
Jun 9, 2009·Cell Cycle·Gaspare La RoccaRenato Baserga
Jul 7, 2009·Nature·Kimberly R CordesDeepak Srivastava
Aug 20, 2009·The Journal of Clinical Investigation·Thomas BoettgerThomas Braun
Dec 10, 2009·Science Signaling·Alma ZerneckeChristian Weber
Feb 4, 2010·Journal of Lipid Research·Dimitrios IliopoulosVassilis I Zannis
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xiaomei QinNanping Wang
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kuei-Chun WangShu Chien
Feb 16, 2010·Biochemical and Biophysical Research Communications·Martina WeberCharles D Searles
Mar 17, 2010·Biochemical and Biophysical Research Communications·Menno HoekstraErik A L Biessen
Apr 16, 2010·Endocrinology·Francesca E GordonAnne Klibanski
May 15, 2010·Science·S Hani Najafi-ShoushtariAnders M Näär
May 15, 2010·Science·Katey J RaynerCarlos Fernández-Hernando
Jul 3, 2010·Circulation Research·Stephan FichtlschererStefanie Dimmeler
Sep 22, 2010·Journal of Cellular Physiology·Nicholas J LeeperJoshua M Spin
Mar 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Chih-Wen NiHanjoong Jo
May 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Qinbo ZhouShusheng Wang
Jun 8, 2011·The Journal of Clinical Investigation·Katey J RaynerKathryn J Moore
Jul 27, 2011·Circulation·Jan FiedlerThomas Thum
Aug 6, 2011·Stroke; a Journal of Cerebral Circulation·Francesco CipolloneFiamma Buttitta
Aug 13, 2011·Circulation Research·Susmita SahooDouglas W Losordo

❮ Previous
Next ❯

Citations

Jul 1, 2016·Cardiovascular Research·Rokas NavickasPaul Holvoet
Oct 26, 2016·Nitric Oxide : Biology and Chemistry·Da-Bin KuangXiao-Ping Chen
Jul 13, 2016·Cardiovascular Research·Wouter Vandevelde, Karin R Sipido
Jan 21, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hou-Fu XiaGang Chen
May 20, 2017·Cardiovascular Research·Karin R Sipido, Wouter Vandevelde
Apr 22, 2017·European Heart Journal·Wolfgang PollerUlf Landmesser
Feb 8, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Xian-Ke Qiu, Jun Ma
Jan 13, 2018·Frontiers in Endocrinology·Joshua P H NealeDaryl O Schwenke
Nov 27, 2018·Cardiovascular Research·Heather Y Small, Tomasz J Guzik
Nov 6, 2018·The Kaohsiung Journal of Medical Sciences·Lu WangZhou Liu
Oct 5, 2018·European Heart Journal. Cardiovascular Pharmacotherapy·Josip A BorovacFilippo Crea
Feb 27, 2018·Journal of Extracellular Vesicles·Sebastian BoroschSandra Kraemer
Oct 13, 2019·Cardiovascular Research·Anne Yaël Nossent
Oct 19, 2019·Journal of Clinical Medicine·Stasė GasiulėGiedrius Vilkaitis
Nov 17, 2019·Clinical and Experimental Medicine·Joyita BanerjeeNeetu Mishra
Jul 30, 2016·Current Opinion in Lipidology·Lin DengAndrew H Baker
Jul 8, 2017·Antioxidants & Redox Signaling·Paola FuschiFabio Martelli
Dec 1, 2019·International Journal of Molecular Sciences·Anne Yaël NossentThomas Gremmel
Dec 19, 2019·Journal of Clinical Medicine·Emma L SollyJoanne T M Tan
Jul 30, 2017·Journal of Translational Medicine·Christoph S NabzdykFrank W LoGerfo
May 26, 2018·Cardiovascular Research·Heather Y Small, UNKNOWN FCVB Young Investigators
Aug 24, 2019·Frontiers in Cardiovascular Medicine·Eveline A C GoossensA Yaël Nossent
May 13, 2017·BioMed Research International·Hui WangYihua Bei
Dec 29, 2019·Cells·Reginald V C T van der KwastA Yaël Nossent
Jan 18, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A PanaritiQ Hamid
May 13, 2018·Non-coding RNA·Gabriel A CipollaDaniela F Gradia
Dec 31, 2019·Cardiology Research and Practice·Václava ČernáMartin Pešta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

American Journal of Physiology. Heart and Circulatory Physiology
Yuanyuan WeiChristian Weber
Thrombosis and Haemostasis
M Nazari-JahantighA Schober
Methods in Molecular Biology
Julia Winter, Sven Diederichs
Current Drug Targets
Angelika BonauerStefanie Dimmeler
© 2022 Meta ULC. All rights reserved