The multiple action of bradykinin on smooth muscle of guinea-pig taenia caeci

European Journal of Pharmacology
A Den HertogJ Van den Akker

Abstract

The action of bradykinin on the smooth muscle of guinea-pig taenia caeci was studied by measuring changes in membrane potential, the contractile state of the muscle cells and intracellular calcium concentrations at 22 degrees C in the presence of tetrodotoxin, yohimbine, prazosin, propranolol and atropine. The bradykinin response was characterised by an initial hyperpolarization and suppression of spike activity followed by a sustained depolarization and an increased spike activity accompanied by inhibition of the phasic contractions, an increase in muscle tone and the development of phasic contractions, respectively. The actions of bradykinin were not affected after B1-bradykinin receptors were blocked with des-Arg9-[Leu8]bradykinin. The events induced by bradykinin were accompanied by an increase in the intracellular calcium concentration, as monitored by quin-2 fluorescence. The hyperpolarization and depolarization persisted in the presence of diltiazem (10(-5) M) and in calcium-free conditions. The hyperpolarization could be evoked only once in the absence of calcium and was inhibited in the presence of apamin and after stimulation of alpha 1-adrenoceptors or P2-purinoceptors. Membrane conductance was decreased during the s...Continue Reading

References

Sep 15, 1979·European Journal of Pharmacology·A J Maas, A Den Hertog
Oct 22, 1985·European Journal of Pharmacology·K S Hwang, C Van Breemen
Mar 11, 1986·European Journal of Pharmacology·A Den Hertog, J Van den Akker
Jul 5, 1987·Nature·R F Irvine
Mar 31, 1987·European Journal of Pharmacology·N TodaT Okamura
Mar 11, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E Bülbring, T Tomita
Jul 1, 1981·The Journal of Physiology·A Den Hertog

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Citations

Feb 7, 1991·European Journal of Pharmacology·J M Hall, I K Morton
Nov 1, 1992·Pharmacology & Therapeutics·J M Hall
Dec 1, 1992·British Journal of Pharmacology·T FeresT B Paiva
Apr 1, 1990·Medicinal Research Reviews·R M BurchL R Steranka

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