The multiple effects of ketamine on electroencephalographic activity and behavior in WAG/Rij rats

Pharmacology, Biochemistry, and Behavior
I MidzyanovskayaE L van Luijtelaar

Abstract

The effects of ketamine, a noncompetitive antagonist at the NMDA receptor, were studied on the EEG and in the open field in a genetic animal model of generalized absence epilepsy--the WAG/Rij rat strain. Animals of this strain display spontaneous occurring generalized spike-wave discharges (SWDs) in the EEG. Ketamine was systemically administered in a dose range from 3 to 30 mg/kg. Biphasic effects of ketamine were observed in the EEG. The first phase was a dose-dependent suppression of SWDs, followed by a second phase characterized by the facilitation of SWDs. This increase was expressed first as an increased number of SWDs, and later on as a significant prolongation of individual discharges and decrease in frequency of SWDs. An obvious amplitude modulation of the discharges was also found. During the period of suppression of SWDs, a new phenomenon was observed: quasi-periodic groups of spikes or wave spikes, with an internal frequency of 4-5 Hz and a periodicity of about 5 s. That quasi-periodic activity vanished a few minutes prior to the recovery of the classical SWDs. However, a specific 5-s amplitude modulation of SWDs remained present in the recovery period. The propensity of that specific ketamine-induced activity was f...Continue Reading

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Citations

Jul 2, 2009·Brain : a Journal of Neurology·Krista M RodgersDaniel S Barth
Jul 12, 2008·Epilepsia·Sofiane BoucettaIgor Timofeev
Aug 14, 2009·Epilepsia·Karine Yu SarkisovaGilles van Luijtelaar
Sep 8, 2015·Journal of Neuroscience Methods·Sylvain ChauvetteIgor Timofeev
Jan 3, 2013·Neurochemistry International·Patricia Graciela Schneider, Georgina Rodríguez de Lores Arnaiz
Jan 26, 2006·Journal of Neuroscience Methods·Daria BosnyakovaGilles van Luijtelaar
Sep 25, 2004·Pharmacology, Biochemistry, and Behavior·I S MidzyanovskayaE L J M van Luijtelaar

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