The multiple faces of Langerhans cell histiocytosis in childhood: A gentle reminder

Molecular and Clinical Oncology
Maria PapadopoulouEfimia Papadopoulou-Alataki

Abstract

Langerhans cell histiocytosis (LCH) is a rare hematologic disorder that results from the clonal multiplication and accumulation of immature dendritic Langerhans cells. Its reported incidence rate varies, but is considered to be 2.6-8.9 per million children who are <15 years of age each year. It may affect any system or organ. The present study reported 4 pediatric LCH cases in order to highlight the heterogeneity of the initial presentation, and the pitfalls that may mislead clinicians and delay diagnosis. The clinical features, as well as the pathognomonic imaging, pathology findings and treatment options were presented. LCH may be rare, but it should always be included in the differential diagnosis of persistent eczema, unexplained skin lesions, diabetes insipidus and persistent bone pain, among others. While the debate on pathogenesis and treatment is ongoing, high index of suspicion among pediatricians, pediatric oncologists and other specialists (pathologists, dermatologists, orthopaedic surgeons, general practitioners or family physicians) is essential for early diagnosis, and optimal outcome.

References

Mar 17, 2005·Pediatric Blood & Cancer·M MinkovH Gadner
Nov 2, 2005·Pediatric Blood & Cancer·Loretta LauSheila Weitzman
Feb 13, 2008·Pediatric Blood & Cancer·Helen StålemarkJan-Inge Henter
Mar 2, 2010·Cancer Treatment Reviews·Oussama AblaSheila Weitzman
May 4, 2011·Pediatrics in Review·Jan E Drutz
Aug 22, 2012·Annual Review of Pathology·Gayane Badalian-VeryBarrett J Rollins
Apr 17, 2013·Blood·Helmut GadnerUNKNOWN Histiocyte Society
Oct 14, 2014·Cancer Control : Journal of the Moffitt Cancer Center·Nanette Grana
Apr 2, 2015·Blood·Carl E AllenKenneth L McClain
Apr 14, 2016·Oncology Letters·Chen LiangShiwen Guo

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Citations

Jan 19, 2021·Proceedings·Andrew L JuergensGuy H Grayson

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