The multiple functions and mechanisms of osteopontin

Clinical Biochemistry
Mehmet Arif Icer, Makbule Gezmen-Karadag

Abstract

Osteopontin (OPN) is a highly phosphorylated glycophosphoprotein having acidic characteristics and rich in aspartic acid. OPN, a multifunctional protein, has important functions on cardiovascular diseases, cancer, diabetes and kidney stone diseases and in the process of inflammation, biomineralization, cell viability and wound healing. Osteopontin acts on organisms by playing a key role in secretion levels of interleukin-10 (IL-10), interleukin-12 (IL-12), interleukin-3 (IL-3), interferon-γ (IFN-γ), integrin αvB3, nuclear factor kappa B (NF-kB), macrophage and T cells, regulating the osteoclast function and affecting CD44 receptors. The aim of the present review is to address majority of different functions of OPN protein which are known, suspected or suggested through the data obtained about this protein yet.

Citations

Feb 20, 2019·Cells·Luigi Mario CastelloAnnalisa Chiocchetti
Apr 20, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josh LevitskyGoran Klintmalm
Jun 25, 2019·Critical Reviews in Food Science and Nutrition·Mehmet Arif Icer, Hilal Yıldıran
May 19, 2019·Biomolecules·Fanindra Kumar DeshmukhMichal Sharon
Jul 19, 2019·The Journal of International Medical Research·Hangdi XuFangfang Fu
Aug 15, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kavish R PatidarTarek M El-Achkar
Feb 14, 2020·Renal Failure·Dong-Jin Oh
Feb 28, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali NazmiDanyvid Olivares-Villagómez
Jun 17, 2020·Biomedical Materials·Mariah SarwatAurelien Forget
Apr 1, 2020·Pediatric Blood & Cancer·Nasenien Nourkami-TutdibiErol Tutdibi
Jan 9, 2019·Frontiers in Physiology·Camila Iansen IrionLina A Shehadeh
Mar 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Emanuele FerrariPier Luigi Mauri
Sep 11, 2019·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mourad AssidiJaudah Al-Maghrabi
Jan 9, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Itzel Y RojasCraig R Tomlinson
Jul 14, 2020·Journal of Cellular and Molecular Medicine·Yunxiang ZhouAnwen Shao
Aug 7, 2019·Cells·Anne-Sophie LamortGeorgios T Stathopoulos
Dec 28, 2019·International Journal of Molecular Sciences·Go AnanChikara Ohyama
Jul 10, 2020·International Journal of Molecular Sciences·Daniel Feng, Casimiro Gerarduzzi
Aug 13, 2020·Pediatric Diabetes·Maria Loredana MarcovecchioUNKNOWN AdDIT and the SDRNT1BIO Investigators
Sep 25, 2019·Materials·Madalina Georgiana NeculaAnisoara Cimpean
Dec 11, 2019·Cells·Iman Abdelaziz MohamedFatima Mraiche
Aug 15, 2020·Frontiers in Cell and Developmental Biology·Stephen J BushDavid A Hume
Aug 8, 2020·International Journal of Molecular Sciences·Elena VianelloMassimiliano Marco Corsi Romanelli
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elena TibaldiAnna Maria Brunati
Apr 23, 2020·Frontiers in Immunology·Anouk Benmamar-BadelAgnieszka Wlodarczyk
Mar 22, 2020·International Journal of Molecular Sciences·Eva Nora BukoszaChristoph A Gebeshuber
Nov 7, 2019·Nutrients·Manuel F LandechoGema Frühbeck
Oct 8, 2020·International Journal of Molecular Sciences·Andreas KronbichlerJae Il Shin
Nov 17, 2020·Journal of the American Heart Association·Laura E BruijnJan H N Lindeman
Dec 4, 2020·Neural Regeneration Research·Giuseppe CappellanoCristoforo Comi
Dec 11, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Maria L MaceEwa Lewin
Feb 5, 2021·Journal of Proteomics·J WillforssP Humblot

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

The Journal of Surgical Research
Philip Y Wai, Paul C Kuo
Nihon rinsho. Japanese journal of clinical medicine
Y NihoS Okamura
The Journal of Clinical Endocrinology and Metabolism
Javier Gómez-AmbrosiGema Frühbeck
© 2022 Meta ULC. All rights reserved