The multiple functions of Numb.

Experimental Cell Research
Alberto GulinoIsabella Screpanti

Abstract

Numb is an evolutionary conserved protein that plays critical roles in cell fate determination. Mammalian Numb displays a higher degree of structural complexity compared to the Drosophila homolog based on the number of encoding genes (Numb and Numb-like) and of alternative spliced isoforms. Accordingly, Numb proteins display a complex pattern of functions such as the control of asymmetric cell division and cell fate choice, endocytosis, cell adhesion, cell migration, ubiquitination of specific substrates and a number of signaling pathways (i.e. Notch, Hedgehog, p53). Recent findings indicate that, besides controlling such physiologic developmental processes, subversion of the above Numb-dependent events plays a critical role in disease (e.g. cancer). We will review here the multiple functions of mNumb and their underlying molecular mechanisms in development and disease.

References

Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·J M VerdiH D Lipshitz
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·W ZhongY N Jan
Dec 21, 2000·The Journal of Cell Biology·E SantoliniP P Di Fiore
Jun 20, 2001·Current Biology : CB·O ZilianM Aguet
Nov 2, 2001·Nature·T ReyaI L Weissman
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·L SusiniA Telerman
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Roberta RoncaratiLuciano D'Adamio
Nov 26, 2002·Nature Neuroscience·Michel Cayouette, Martin Raff
Apr 19, 2003·The Journal of Biological Chemistry·Melanie A McGill, C Jane McGlade
Jan 20, 2004·Developmental Biology·Anne-Laurence KleinVerdon Taylor
May 25, 2004·Molecular Biology of the Cell·Christian A SmithC Jane McGlade
Oct 20, 2004·The Journal of Cell Biology·Salvatore PecePier Paolo Di Fiore
Aug 18, 2005·The Journal of Biological Chemistry·Hiroshi TokumitsuRyoji Kobayashi
Sep 6, 2005·Nature Genetics·Emmanuel Caussinus, Cayetano Gonzalez
Dec 22, 2005·Development·Konstantinos MeletisJonas Frisén
Jun 27, 2006·Nature Cell Biology·Vasily ShininShahragim Tajbakhsh
Jun 27, 2006·Nature·Andreas Androutsellis-TheotokisRonald D G McKay
Nov 23, 2006·Nature Cell Biology·Lucia Di MarcotullioAlberto Gulino
Nov 23, 2006·The Journal of Cell Biology·Gavin ChapmanUrban Lendahl
Dec 22, 2006·Genes & Development·Hongyan WangWilliam Chia
Jan 27, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mahmud Bani-YaghoubJoseph M Verdi
Jul 5, 2007·Developmental Cell·Takashi Nishimura, Kozo Kaibuchi
Jan 4, 2008·Nature·Ivan N ColalucaPier Paolo Di Fiore
Feb 26, 2008·Cell·Juergen A Knoblich
May 21, 2008·The Journal of Cell Biology·Hironori KawaharaHideyuki Okano
Jul 16, 2008·Biochimica Et Biophysica Acta·Claudio TaloraIsabella Screpanti
Nov 26, 2008·Biochemical and Biophysical Research Communications·Wei KuangYanpu Liu
Dec 17, 2008·Developmental Cell·Jin Jiang, Chi-Chung Hui
Jul 2, 2009·The Journal of Biological Chemistry·Melanie A McGillC Jane McGlade
Jul 18, 2009·The EMBO Journal·Zezhou WangShawn Shun-Cheng Li

❮ Previous
Next ❯

Citations

Mar 26, 2014·Cell Research·Marika SjöqvistCecilia Sahlgren
May 21, 2014·ELife·Benoit G Bruneau
Jan 26, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Jong-Sun Kang, Robert S Krauss
Aug 13, 2010·Development·Mary Redmond HutsonMargaret L Kirby
Aug 31, 2010·Nucleic Acids Research·Kai WangJinze Liu
Nov 3, 2010·Molecular and Cellular Biology·Christine M Misquitta-AliBenjamin J Blencowe
Dec 1, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Gregory W Charville, Thomas A Rando
Jan 24, 2012·Nature Cell Biology·Lydie CouturierFrançois Schweisguth
Feb 20, 2013·The Journal of Cell Biology·Kee K KimSachiyo Kawamoto
Aug 2, 2012·The Journal of Cell Biology·Julien BellisJan R De Mey
Jul 3, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Yi-Chao ShiWei-Fen Xie
Dec 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Gaurav SwarnkarYousef Abu-Amer
Dec 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Liang ZhouYing Shen
Sep 24, 2011·Experimental Cell Research·Philipp EuskirchenHrvoje Miletic
Sep 7, 2011·Biochemical and Biophysical Research Communications·Lining LiuDebashish Das
Oct 14, 2010·Biochimica Et Biophysica Acta·Salvatore PecePier Paolo Di Fiore
Mar 6, 2016·Cancer Letters·Eva García-AlegríaJavier León
Sep 12, 2015·Toxicon : Official Journal of the International Society on Toxinology·Aisha L SiebertJohn H Werren
Jul 20, 2010·Stem Cells·Maria Carolina Florian, Hartmut Geiger
Dec 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jin SimaYanxin Mao
Jul 11, 2013·BioMed Research International·Haitao LiAnne George
Sep 29, 2011·Biochemical and Biophysical Research Communications·Xin-Hua LiuChristopher P Cardozo
Apr 24, 2015·Frontiers in Cellular Neuroscience·Chan Choo Yap, Bettina Winckler
Jul 17, 2012·Cell Adhesion & Migration·Grégoire F Le BrasClaudia D Andl
Mar 20, 2015·Oncology Letters·Chao WangLina Hu
Apr 12, 2014·Journal of Theoretical Biology·A BartonE Rotondo
Apr 8, 2014·Biochemical and Biophysical Research Communications·Sung-Young KimInsuk So
Nov 9, 2010·Experimental Eye Research·Federico Castro-Muñozledo, Eber Gómez-Flores
Mar 23, 2011·Developmental Biology·Sólveig ThorsteinsdóttirFernanda Bajanca
Mar 15, 2015·Frontiers in Oncology·Salvatore CorallinoGiorgio Scita
Mar 25, 2016·Molecular Biology of the Cell·Woan-Yuh TarnIng-Ming Chiu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Cell Fate Specification

Cell fate specification is determined by complex signal transduction pathways including Notch and the Sonic hedgehog signaling pathway. Here is the latest research on regulation of cell fate determination.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Biochimica Et Biophysica Acta
Salvatore PecePier Paolo Di Fiore
Biochemical and Biophysical Research Communications
Lining LiuDebashish Das
Proceedings of the National Academy of Sciences of the United States of America
J M VerdiH D Lipshitz
© 2022 Meta ULC. All rights reserved