The multiple phases and faces of wnt signaling during cardiac differentiation and development

Circulation Research
Susanne Gessert, M Kühl

Abstract

Understanding heart development on a molecular level is a prerequisite for uncovering the causes of congenital heart diseases. Therapeutic approaches that try to enhance cardiac regeneration or that involve the differentiation of resident cardiac progenitor cells or patient-specific induced pluripotent stem cells will also benefit tremendously from this knowledge. Wnt proteins have been shown to play multiple roles during cardiac differentiation and development. They are extracellular growth factors that activate different intracellular signaling branches. Here, we summarize our current understanding of how these factors affect different aspects of cardiogenesis, starting from early specification of cardiac progenitors and continuing on to later developmental steps, such as morphogenetic processes, valve formation, and establishment of the conduction system.

References

Aug 1, 1990·Developmental Biology·A K Sater, A G Jacobson
Jan 1, 1997·Developmental Biology·G L RadiceR O Hynes
May 1, 1997·Mechanisms of Development·Y Landesman, S Y Sokol
Aug 4, 1999·Nature Genetics·P LiuA Bradley
Sep 4, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C A Eisenberg, L M Eisenberg
Jan 5, 2000·Genes & Development·T P YamaguchiA P McMahon
Feb 9, 2000·The Journal of Cell Biology·J HuelskenW Birchmeier
Feb 13, 2001·Genes & Development·V A Schneider, M Mercola
Feb 13, 2001·Genes & Development·M J MarvinA B Lassar
May 23, 2001·Trends in Cardiovascular Medicine·Y SagaS Miyagawa-Tomita
Jan 11, 2002·Developmental Biology·C H MjaatvedtR R Markwald
Sep 26, 2002·Developmental Biology·Alin Vonica, Barry M Gumbiner
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Teruya NakamuraMichael D Schneider
Jul 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jacqueline BondRobert G Gourdie
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hidemasa OhMichael D Schneider
Oct 10, 2003·Nature·Adam F L HurlstoneHans Clevers
Dec 4, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Aaron D GitlerPeter J Gruber
Apr 7, 2004·The Journal of Biological Chemistry·Peter MayeDianqing Wu
May 8, 2004·Developmental Cell·Sigolène M MeilhacMargaret E Buckingham
Jun 26, 2004·Circulation Research·Stéphane ZaffranNigel A Brown
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse
Nov 16, 2004·Biochemical and Biophysical Research Communications·Hiromi TeramiTakayuki Morisaki
Jan 5, 2005·Genes & Development·Takaaki MatsuiJuan Carlos Izpisúa Belmonte
Feb 3, 2005·Genes & Development·Ann C Foley, Mark Mercola
Feb 11, 2005·The Journal of Biological Chemistry·Masamichi KoyanagiStefanie Dimmeler
Feb 11, 2005·Nature·Karl-Ludwig LaugwitzKenneth R Chien
Apr 29, 2005·Development·Jaime De CalistoRoberto Mayor
Jul 22, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jun K YamashitaShin-Ichi Nishikawa
Sep 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Valerie KouskoffGordon Keller

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Citations

May 11, 2011·Development Genes and Evolution·Yanchun GuoMichael Kühl
Apr 25, 2012·Development Genes and Evolution·Petra PandurMichael Kühl
Jul 10, 2012·Biomechanics and Modeling in Mechanobiology·Sean P SheehyKevin Kit Parker
Dec 3, 2010·Current Hypertension Reports·Genevieve Nguyen
Oct 16, 2013·Reproductive Biomedicine Online·Alan Trounson
Jul 29, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Pitchai Balakumar, Gowraganahalli Jagadeesh
Mar 31, 2011·Acta Physiologica·P Uysal-Onganer, R M Kypta
Dec 2, 2011·Journal of Biomedicine & Biotechnology·Gang WuDezhi Mu
Oct 29, 2011·Circulation Research·Angelos OikonomopoulosRonglih Liao
Jul 18, 2012·Circulation Research·Brandi BaileyMark A Sussman
Aug 25, 2011·Development·Hillary F McGrawAlexei V Nechiporuk
May 3, 2013·PloS One·Thomas B NicholsonTaiping Chen
Dec 11, 2013·Stem Cells Translational Medicine·Ioannis KarakikesRoger J Hajjar
Oct 1, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Ivana BulatovicKarl-Henrik Grinnemo
Jan 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Peter HofsteenCharles E Murry
Jan 20, 2016·Journal of Cellular and Molecular Medicine·Yihao WuYong-jian Geng
Dec 19, 2012·Trends in Endocrinology and Metabolism : TEM·Danese M JoinerBart O Williams
Aug 21, 2012·Trends in Endocrinology and Metabolism : TEM·K MarinouM Koutsilieris
Aug 21, 2012·Trends in Cardiovascular Medicine·Julia Norden, Andreas Kispert
May 26, 2012·Trends in Cardiovascular Medicine·Alexander Kleger, Stefan Liebau
Dec 24, 2015·Frontiers in Cell and Developmental Biology·Nazanin F DolatshadGabor Földes
Jun 15, 2015·Journal of Molecular and Cellular Cardiology·Jeffrey SchmeckpeperMaria Mirotsou
Dec 3, 2015·Biochemical and Biophysical Research Communications·Aric PahnkeMilica Radisic
Dec 1, 2015·Trends in Biotechnology·Ali K YetisenSeok Hyun Yun

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