The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells

Genes and Immunity
Tone BergeAnne Spurkland

Abstract

Multiple sclerosis (MS) is an inflammatory, demyelinating disorder of the central nervous system that develops in genetically susceptible individuals. The majority of the MS-associated gene variants are located in genetic regions with importance for T-cell differentiation. Vitamin D is a potent immunomodulator, and vitamin D deficiency has been suggested to be associated with increased MS disease susceptibility and activity. In CD4+ T cells, we have analyzed in vitro vitamin D responsiveness of genes that contain an MS-associated single-nucleotide polymorphism (SNP) and with one or more vitamin D response elements in their regulatory regions. We identify IL2RA and TAGAP as novel vitamin D target genes. The vitamin D response is observed in samples from both MS patients and controls, and is not dependent on the genotype of MS-associated SNPs in the respective genes.

References

Sep 16, 1983·Science·D M ProvvediniS C Manolagas
Jun 29, 1984·Science·C D TsoukasS C Manolagas
May 2, 1998·Nutrition Reviews·H F DeLuca, C Zierold
Feb 10, 2000·Archives of Biochemistry and Biophysics·C M VeldmanH F DeLuca
May 7, 2002·The Journal of Biological Chemistry·Lionel DrocourtMarie-José Vilarem
Aug 22, 2002·International Immunopharmacology·Luciano Adorini
Dec 10, 2002·Biochemical and Biophysical Research Communications·Paul D ThompsonMark R Haussler
Nov 17, 2004·Trends in Biochemical Sciences·David E Prosser, Glenville Jones
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sheng ChenPeter E Lipsky
Jan 8, 2008·Journal of Neuroimmunology·Joost SmoldersRaymond Hupperts
Jan 24, 2008·Nature Clinical Practice. Endocrinology & Metabolism·John S Adams, Martin Hewison
Jul 9, 2008·Neurology·Alvaro Alonso, Miguel A Hernán
Jul 16, 2008·Molecular Aspects of Medicine·Femke BaekeChantal Mathieu
Aug 30, 2008·Autoimmunity Reviews·Alessandra B Pernis
Mar 27, 2009·Brain : a Journal of Neurology·Jorge CorrealeMaría Inés Gaitán
Jul 28, 2009·Current Osteoporosis Reports·Daniel D Bikle
Oct 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Louisa E JefferyDavid M Sansom
Mar 9, 2010·Nature Immunology·Marina Rode von EssenCarsten Geisler
Mar 20, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Juha M MatilainenSami Väisänen
Mar 23, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Femke BaekeChantal Mathieu
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Mar 11, 2011·Genes and Immunity·R ChenR M Plenge
May 31, 2011·Autoimmunity Reviews·Evelyn PeelenJan Damoiseaux
Aug 13, 2011·Nature·UNKNOWN International Multiple Sclerosis Genetics ConsortiumAlastair Compston
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Mark R HausslerAnthony W Norman
Feb 22, 2012·Nature Reviews. Immunology·Onur Boyman, Jonathan Sprent
Jun 26, 2012·Immunological Reviews·Pierre-Antoine GourraudSergio E Baranzini

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Citations

Oct 27, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Georgios M HadjigeorgiouEfthimios Dardiotis
Jul 16, 2020·British Journal of Pharmacology·Wei Zhen YehHelmut Butzkueven
Feb 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Manuel ZeitelhoferMaja Jagodic
May 4, 2017·Immunology and Cell Biology·Norimasa TamehiroHarumi Suzuki
Dec 12, 2019·Frontiers in Immunology·Farhan CyprianGuillermina Girardi
Mar 14, 2019·F1000Research·Aaron GregsonDavid L Selwood
Jun 13, 2020·Immunometabolism·Colleen E Hayes, James M Ntambi
Nov 13, 2020·Reports of Biochemistry & Molecular Biology·Mohsen AsouriHaleh Akhavan-Niaki
May 1, 2021·Frontiers in Immunology·Emma L BishopSarah Dimeloe

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Methods Mentioned

BETA
genotyping
PCR
flow cytometry
immunoprecipitation
ChIP
electrophoresis

Software Mentioned

ImmunoChip
ImageJ
Attune Cytometric
FlowJo
Graph Pad Prism

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