PMID: 11323403Apr 27, 2001Paper

The multiplicative model for cancer risk assessment: applicability to acrylamide

Carcinogenesis
B PaulssonM Törnqvist

Abstract

According to a multiplicative model for prediction of cancer risk for genotoxic agents the incremental cancer risk is, for low-intermediate exposures, proportional to target doses of the genotoxic substance and to the background risk in control groups. This model has been applied to evaluate cancer tests of acrylamide in rodents. Because of its reactivity toward DNA, glycidamide is assumed to be the causative genotoxic metabolite of acrylamide. Evaluation of experimental data according to the multiplicative model shows that mice, compared with rats, are of the order of 10 times more sensitive per administered dose of acrylamide. The US EPA procedure would, however, generally predict rats to be about twice as sensitive as mice to carcinogenic chemicals, because their estimates are based on scaling of the dose per square meter body surface area, as a surrogate for metabolic differences between the species. The comparison of rats and mice with respect to observed cancer incidence is at a key position in the evaluation of the usefulness of risk models for extrapolation between species. In the present study mice and rats were compared, with respect to in vivo doses of acrylamide and the metabolite glycidamide, after exposure to acry...Continue Reading

Citations

Jan 11, 2008·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz· Kommission Human-Biomonitoring des Umweltbundesamtes
Jul 28, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Tatiana Katsaiti, Kit Granby
Nov 25, 2004·Journal of Biochemical and Biophysical Methods·M Murkovic
Jan 20, 2011·International Journal of Environmental Health Research·Boris A Korobitsyn
Jan 10, 2008·International Journal of Cancer. Journal International Du Cancer·Pelle Thonning OlesenAnne Tjønneland
Jul 28, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Timothy R FennellMarvin A Friedman
Oct 12, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·M TörnqvistP Rydberg
Jul 16, 2008·Journal of Agricultural and Food Chemistry·Margareta TörnqvistFredrik Granath

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