PMID: 11915940Mar 28, 2002Paper

The murine complement regulator Crry: new insights into the immunobiology of complement regulation

Cellular and Molecular Life Sciences : CMLS
Hector Molina

Abstract

Complement has an important role in inflammation and in the normal function of the immune system. Activated complement fragments have the capacity to bind and damage self-tissues. Cells from vertebrates express on their surface regulators of complement activation that protect them from the deleterious effects of cell-bound complement fragments. Abnormalities in these regulators of complement activation may participate in the pathogenesis of autoimmune diseases and inflammatory disorders. Murine Crry is one of these regulators that inhibits the activation of the third component of complement and protects self-tissues from complement-mediated damage. Experimental work on Crry has increased our understanding of the immunobiology of complement regulation and the potential role of complement and complement inhibitors in the development and treatment of human diseases.

Citations

Oct 4, 2005·Springer Seminars in Immunopathology·M Kathryn LiszewskiJohn P Atkinson
Oct 6, 2007·Immunologic Research·Brian K Martin
Apr 16, 2005·Clinical Microbiology Reviews·Alain L Servin
Jun 27, 2007·Investigative Ophthalmology & Visual Science·Elaine C JohnsonJohn C Morrison
Jul 13, 2012·Investigative Ophthalmology & Visual Science·Yan LiFeng Lin
Sep 11, 2010·FEBS Letters·Edwin D Hawkins, Jane Oliaro
Feb 11, 2009·Molecular Reproduction and Development·Wang-Ngai ChowWilliam Shu-Biu Yeung
Nov 2, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J Wen DingA S Chong
Jul 11, 2008·Immunological Reviews·V Michael Holers
May 19, 2004·Neuroscience Letters·Anette StorsteinChristian Vedeler
Aug 6, 2013·Journal of Toxicologic Pathology·Chie KatoMasami Suzuki
Sep 8, 2019·Metabolomics : Official Journal of the Metabolomic Society·Pamela Xing Yi SohPeter Williamson
Jul 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Svetlana N TchepelevaSusan A Boackle
Dec 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keith M WoodsSherry D Fleming
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rebecca C RileyJohn P Atkinson
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Uwe KoedelCarsten J Kirschning
Sep 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard J Quigg
Feb 8, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lidia BarataWen-Chao Song
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dirk SpitzerJohn P Atkinson
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·David D KimWen-Chao Song
Jun 11, 2021·Immunology Letters·Lazara Elena Santiesteban-LoresLorena Bavia

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