The murine Dax-1 promoter is stimulated by SF-1 (steroidogenic factor-1) and inhibited by COUP-TF (chicken ovalbumin upstream promoter-transcription factor) via a composite nuclear receptor-regulatory element

Molecular Endocrinology
R N YuJ Larry Jameson

Abstract

The Dax-1 gene encodes a protein that is structurally related to members of the orphan nuclear receptor superfamily. Dax-1 is coexpressed with another orphan nuclear receptor, steroidogenic factor-1 (SF-1), in the adrenal, gonads, hypothalamus, and pituitary gland. Mutations in Dax-1 cause adrenal hypoplasia congenita, a disorder that is characterized by adrenal insufficiency and hypogonadotropic hypogonadism. These developmental and endocrine abnormalities are similar to those caused by disruption of the murine Ftz-F1 gene (which encodes SF-1), suggesting that these nuclear receptors act along the same developmental cascade. Cloning of the murine Dax-1 gene revealed a candidate SF-1-binding site in the Dax-1 promoter. In transient expression assays in SF-1-deficient JEG-3 cells, SF-1 stimulated expression of the Dax-1 promoter. However, deletion or mutation of the consensus SF-1-binding site did not eliminate SF-1 stimulation. Further analyses revealed the presence of a cryptic SF-1 site that creates an imperfect direct repeat of the SF-1 element. When linked to the minimal thymidine kinase promoter, each of the isolated SF-1 sites was sufficient to mediate transcriptional regulation by SF-1. Mutation of both SF-1 sites elimin...Continue Reading

Citations

Apr 8, 2010·Pharmaceutical Research·Subhajit Mukherjee, Sridhar Mani
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·M L BlandH A Ingraham
Apr 2, 2004·The Journal of Biological Chemistry·Lisa M SalvadorMary Hunzicker-Dunn
Nov 7, 2008·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·L Lin, J C Achermann
Sep 12, 2012·Journal of Molecular Endocrinology·Lacey M Litchfield, Carolyn M Klinge
Nov 10, 2000·Biochemical and Biophysical Research Communications·R KimuraK Morohashi
Aug 21, 2013·Gene·Rute S T MartinsAdelino V M Canário
Jan 17, 2009·BMC Genetics·Mahmoud A AlfaqihGary H Thorgaard
Dec 25, 2004·Clinical Genetics·A Fleming, E Vilain
Oct 22, 2003·Molecular Genetics and Metabolism·Robert Clipsham, Edward R B McCabe
Jan 24, 2012·Molecular and Cellular Endocrinology·Derek P Simon, Gary D Hammer
Jun 16, 2011·Molecular and Cellular Endocrinology·Unmesh JadhavJ Larry Jameson
Aug 28, 2010·Molecular and Cellular Endocrinology·Weiming ZhengLisa M Halvorson
Apr 17, 2010·Annales d'endocrinologie·A Bashamboo, K McElreavey
Jul 21, 2009·Molecular and Cellular Endocrinology·Erling A HoivikMarit Bakke
May 13, 2008·Biochemical and Biophysical Research Communications·Chuanhai SunTakashi Yokota
Aug 12, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Thomas AndrieuHervé Mittre
Jun 1, 2014·Biochimica Et Biophysica Acta·Ke TangMing-Jer Tsai
Dec 26, 2001·Molecular Genetics and Metabolism·R C Clipsham, E R McCabe
Aug 6, 1999·Frontiers in Neuroendocrinology·G D Hammer, H A Ingraham
Jul 6, 2016·Frontiers in Neuroscience·Gavin P Vinson
Jun 6, 2009·Experimental Biology and Medicine·Holly A Lavoie, Steven R King
Oct 3, 2002·Nature Reviews. Genetics·Howard J Cooke, Philippa T K Saunders
Dec 8, 1998·Nature Genetics·R N YuJ L Jameson
Feb 13, 2001·Endocrine Reviews·A LacroixP Hamet
Oct 26, 1999·Endocrine Reviews·V Giguère
May 31, 2003·Molecular Endocrinology·Enzo Lalli, Paolo Sassone-Corsi
Aug 14, 1999·Molecular Endocrinology·K KawabeK Morohashi
Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Bilgin GuratesSerdar E Bulun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.

© 2022 Meta ULC. All rights reserved