PMID: 2500403Jan 1, 1989Paper

The muscarinic agonist pilocarpine inhibits DNA and interferon-gamma synthesis in peripheral blood mononuclear cells

International Journal of Immunopharmacology
E S ArztV E Nahmod

Abstract

Lymphocyte basal DNA synthesis and proliferative responses to phytohemagglutinin (PHA) showed a dose-dependent (5 X 10(-5)-5 X 10(-3) M) inhibition by the muscarinic agonist pilocarpine, in contrast to the basal enhancing effect produced by the M2 muscarinic-nicotinic agonist carbachol. The effect of pilocarpine was reversed by both atropine (1 X 10(-6) M) and pirenzepine (1 X 10(-7)-1 X 10(-8) M), M1-M2 and M1 muscarinic antagonists, respectively. The effect of pilocarpine may thus be specific for the M1 muscarinic receptor. Pilocarpine also inhibited interferon-gamma (IFN-gamma)-PHA induced production, but was unable to reverse the pokeweed mitogen (PWM)-induced DNA synthesis. Distinct immunoregulatory activities are suggested for cholinergic muscarinic receptors M1 and M2.

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Citations

Jan 1, 1994·Journal of Neuroimmunology·P CostaL G Costa
Apr 13, 2000·Pharmacology & Therapeutics·K Kawashima, T Fujii
Jan 1, 1990·Fundamental & Clinical Pharmacology·P J Neveu, M Le Moal
Mar 14, 2013·Investigative Ophthalmology & Visual Science·Yihe ChenReza Dana
Mar 9, 2005·Medical and Veterinary Entomology·K E LedinJ Piesman
Mar 11, 2004·Medical and Veterinary Entomology·J M C RibeiroT N Mather
Jul 25, 2007·Epilepsia·Nicola MarchiDamir Janigro

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