The mushroom body defect gene product is an essential component of the meiosis II spindle apparatus in Drosophila oocytes

Genetics
James X YuH A Nash

Abstract

In addition to their well-known effects on the development of the mushroom body, mud mutants are also female sterile. Here we show that, although the early steps of ovary development are grossly normal, a defect becomes apparent in meiosis II when the two component spindles fail to cohere and align properly. The products of meiosis are consequently mispositioned within the egg and, with or without fertilization, soon undergo asynchronous and spatially disorganized replication. In wild-type eggs, Mud is found associated with the central spindle pole body that lies between the two spindles of meiosis II. The mutant defect thus implies that Mud should be added to the short list of components that are required for the formation and/or stability of this structure. Mud protein is also normally found in association with other structures during egg development: at the spindle poles of meiosis I, at the spindle poles of early cleavage and syncytial embryos, in the rosettes formed from the unfertilized products of meiosis, with the fusomes and spectrosomes that anchor the spindles of dividing cystoblasts, and at the nuclear rim of the developing oocyte. In contrast to its important role at the central spindle pole body, in none of these ...Continue Reading

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Citations

Dec 25, 2008·Journal of Neurogenetics·Anna Hovhanyan, Thomas Raabe
Dec 5, 2015·Frontiers in Cell and Developmental Biology·Jack W C ChenJames G Wakefield
Oct 13, 2015·Nature Cell Biology·Nicolas ChristophorouJean-René Huynh
Jul 31, 2013·Current Biology : CB·Dan T BergstralhDaniel St Johnston
Jun 3, 2006·Developmental Cell·Sarah K BowmanJuergen A Knoblich
Jun 28, 2014·Seminars in Cell & Developmental Biology·Dan T Bergstralh, Daniel St Johnston
Jun 12, 2016·Development·Dan T BergstralhDaniel St Johnston
Mar 30, 2017·Development·Dan T BergstralhDaniel St Johnston
Sep 4, 2021·Frontiers in Cell and Developmental Biology·Fred BernardSandra Claret

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