PMID: 7027032Aug 1, 1981Paper

The mutagenic action of aliphatic epoxides

Mutation Research
C E VoogdJ J Jacobs

Abstract

The mutagenic action of 45 epoxides was investigates in Luria and Delbrück's fluctuation test with Klebsiella pneumoniae as test organism. In this test, 36 of the 45 epoxides appeared to be mutagenic. The mutagenicity of 1,2-epoxides decreased with increasing length of the carbon chain. The mutagenic activity of compounds with a non-terminal epoxide group appeared to be less than that of substances with a terminal one. Generally 1,2-epoxide compounds with electronegative groups were more mutagenic than 1,2-epoxypropane. Of the diepoxides, 1,2,3,4-diepoxybutane appeared to be more mutagenic than 1,2,7,8-diepoxyoctane, while the ring compounds 1,2,5,6-diepoxycyclooctane was hardly mutagenic. The ring compound 4-vinylcyclohexenedioxide, used in electron microscopy that the antibiotic fosfomycin is among the more potent mutagenic substances investigated in this study.

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Citations

Feb 1, 1985·Archives of Toxicology·W von der HudeW Dittmar
Jan 1, 1988·Chemico-biological Interactions·J J SolomonA Segal
Aug 1, 1995·Mutation Research·K L DearfieldD J Brusick
Jan 1, 1985·Mutation Research·B J DeanD H Hutson
May 1, 1988·Mutation Research·C de Meester
Aug 1, 1983·Mutation Research·A M RossiC Pantarotto
Aug 1, 1984·Mutation Research·T H Waegemaekers, M P Bensink
Dec 1, 1985·Mutation Research·K Hashimoto, H Tanii
Jan 1, 1986·Mutation Research·W von der HudeR Braun
Nov 1, 1986·Mutation Research·D A CanterW Speck
Dec 1, 1987·Mutation Research·C VleminckxW Moens
Nov 1, 1987·Mutation Research·L B RosmanJ E Sinsheimer
Sep 1, 1988·Mutation Research·L B RosmanJ E Sinsheimer
Nov 1, 1990·Mutation Research·W von der HudeA Basler
Apr 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H W GardnerJ T MacGregor
Sep 1, 1985·Toxicology·P W WesterG J Van Esch
Aug 15, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·J BaoI G Sipes
Nov 20, 2002·Mutation Research·Helmut SchweiklWolfgang Weinmann
Oct 31, 2012·Chemical Research in Toxicology·Jakub KostalPaul T Anastas
Apr 20, 2007·Chemical Research in Toxicology·Keith P RomanoJulie T Millard
May 4, 2001·Journal of Biomaterials Science. Polymer Edition·D YourteeD Eick
Jun 1, 1990·Environmental Health Perspectives·D TurnbullS M Brett
Jun 1, 1990·Environmental Health Perspectives·G T ArceA M Sarrif
Mar 1, 1997·Mutation Research·A K Giri

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