PMID: 375080Mar 1, 1979Paper

The mutagenic action of nitroimidazoles. IV. A comparison of the mutagenic action of several nitroimidazoles and some imidazoles

Mutation Research
C E VoogdJ J Jacobs

Abstract

The mutagenic action of 51 imidazoles was investigated. The fluctuation test of Luria and Delbrück was used, with Klebsiella pneumoniae as test organism. 8 compounds, including 5 with a weak mutagenic action in the fluctuation test, were also investigated by the Ames test in which Salmonella typhimurium TA100 was used. Of the 51 imidazoles examined, 33 were nitroimidazoles. 31 of the latter appeared to be mutagenic, whereas out of the 18 other imidazoles without a nitro group only 2 were mutagenic. Several of the substances tested for mutagenicity showed an antimicrobial activity. No direct relationship between antimicrobial action, growth inhibition and mutagenicity was established. With methyl-nitroimidazoles a relationship was found between the chemical structure and mutagenic action. However, when the nitroimidazoles had a more complex chemical structure, a relationship between this structure and mutagenicity could not be established.

References

Jun 1, 1977·Journal of General Microbiology·B P GoldsteinL G Silvestri
Jun 1, 1976·Mutation Research·H S RosenkranzJ E Stambaugh
Sep 1, 1976·Antimicrobial Agents and Chemotherapy·D G Lindmark, M Müller
Nov 1, 1976·Mutation Research·M HiteH Peck
Jun 1, 1975·Mutation Research·C E VoogdJ J Jacobs
May 1, 1975·Antimicrobial Agents and Chemotherapy·F P TallyS M Finegold
Apr 1, 1975·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R M IngsW E Ormerod
Feb 1, 1976·Journal of the National Cancer Institute·W T SpeckH S Rosenkranz
Jun 1, 1972·Annals of Tropical Medicine and Parasitology·D R O'Holohan, J Hugoe-Matthews
May 1, 1973·Journal of General Microbiology·D I EdwardsH Carne
Oct 1, 1972·Journal of Medicinal Chemistry·G Asato, G Berkelhammer
Aug 1, 1974·The British Journal of Radiology·J C AsquithJ A McFadzean
Oct 1, 1971·Journal of Medicinal Chemistry·M HofferA Brossi
Nov 1, 1943·Genetics·S E Luria, M Delbrück

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Citations

Jan 1, 1996·Veterinary Research Communications·A PosyniakB Biernacki
Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·K Nagafuchi, K Miyazaki
Jan 1, 1981·Pharmacology & Therapeutics·H MonneyR G Wallace
Jun 1, 1994·Mutation Research·L DobiásR Srám
May 1, 1983·Mutation Research·R Nagel, I Nepomnaschy
Jul 1, 1986·Mutation Research·R C Ferreira, L C Ferreira
Dec 1, 1992·Mutation Research·R ForsterJ Westendorf
Apr 1, 1987·Mutation Research·V F Garry, R L Nelson
May 1, 1987·Mutation Research·R Nagel
Feb 29, 1996·Mutation Research·J J Espinosa-AguirreJ M Hernández
May 25, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Rodrigo H M M GranjaAlessandro G Salerno
Jul 1, 1997·Sexually Transmitted Diseases·G R Saurina, W M McCormack
Dec 1, 1985·Environmental Health Perspectives·S N Moreno, R Docampo
May 26, 2004·Mutation Research·Fabrice NesslanyDaniel Marzin
Oct 30, 2003·Drug and Chemical Toxicology·Hülya ZeytinoğluBerrin Ayaz Tüylü
Jan 1, 1990·Drug Metabolism Reviews·P G Wislocki, A Y Lu
Apr 1, 1984·Journal of Applied Toxicology : JAT·T Shibamoto
Jan 1, 1983·Teratogenesis, Carcinogenesis, and Mutagenesis·G Cantelli-FortiG L Biagi
Sep 7, 2016·Chemistry : a European Journal·Renan B CamposElisa S Orth
Aug 4, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·David BrusickMarisa O Rihner
Feb 10, 1999·Biochemical Pharmacology·C ViodéJ Périé
Nov 15, 1982·Biochemical Pharmacology·G Aicardi, G Solaini
Jun 27, 2021·Regulatory Toxicology and Pharmacology : RTP·Susan J BorghoffGrace A Chappell

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