PMID: 6539929Jul 1, 1984Paper

The mutagenicity of alpha particles in Ehrlich ascites tumor cells

Radiation Research
G Iliakis

Abstract

Cell killing and the induction of mutation to thioguanine resistance (HGPRT enzyme deficiency) were measured after exposure of Ehrlich ascites tumor cells to 150-kV X rays and 241Am alpha particles. The curve describing the induction of mutations was almost linear after exposure to alpha particles (slope: 14.1 x 10(-5) Gy-1) but upward bending after exposure to X rays, apparently reaching a final slope to that obtained after exposure to alpha particles. The number of mutants induced per viable cell by alpha particles at a given level of cell killing was similar to that induced by X rays. The RBE values obtained for cell killing and the induction of mutations are compared with each other, and the possible involvement of repair processes in determining the RBE is discussed.

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