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The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

Jul 22, 2015

Gur YaariYoram Louzoun

Abstract

During the several-week course of an immune response, B cells undergo a process of clonal expansion, somatic hypermutation of the immunoglobulin (Ig) genes and affinity-dependent selection. Over a lifetime, each B cell may participate in multiple rounds of affinity maturation as part of...read more

Mentioned in this Paper

Clonal Selection, Antigen-Mediated
Immune Response
Patterns
MRNA Maturation
Immunoglobulin Activity
Genes
Trees (plant)
Receptors, Antigen, B-Cell
Somatic Mutation
Immunoglobulin Fv Fragments
11
69
Paper Details
References
  • References29
  • Citations10
123
  • References29
  • Citations10
1

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The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

Jul 22, 2015

Gur YaariYoram Louzoun

PMID: 26194756

DOI: 10.1098/rstb.2014.0242

Abstract

During the several-week course of an immune response, B cells undergo a process of clonal expansion, somatic hypermutation of the immunoglobulin (Ig) genes and affinity-dependent selection. Over a lifetime, each B cell may participate in multiple rounds of affinity maturation as part of...read more

Mentioned in this Paper

Clonal Selection, Antigen-Mediated
Immune Response
Patterns
MRNA Maturation
Immunoglobulin Activity
Genes
Trees (plant)
Receptors, Antigen, B-Cell
Somatic Mutation
Immunoglobulin Fv Fragments
11
69

Related Papers

Paper Details
References
  • References29
  • Citations10
123
  • References29
  • Citations10
1
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