The mycobacterial 65 kD heat-shock protein and autoimmune arthritis.

Rheumatology International
Willem van EdenI R Cohen

Abstract

Arthritis - induced experimentally in rats by immunization with mycobacteria has been shown to depend on specific T cell recognition of an epitope present on the mycobacterial 65-kD heat-shock protein. This particular epitope has been observed to have a structural mimicry with a cartilage-associated molecule present in the joints. Since the bacterial heat-shock proteins and the cartilage-associated molecules are of a conserved nature, one might infer from the experimental model that in humans similar mimicry could play a role in the initiation of autoimmune arthritis. Recent findings from the analysis of immunological reactivity to the 65-kD in rheumatoid arthritis patients seem to support such a role for the mycobacterial 65-kD heat-shock protein in human disease.

Citations

Oct 1, 1993·Pain·Hans-Georg Schaible, Blair D Grubb
Feb 8, 2006·Joint, Bone, Spine : Revue Du Rhumatisme·Gaëlle ClavelPatrice Fardellone
Jan 1, 1992·Thyroid : Official Journal of the American Thyroid Association·R S Bahn, A E Heufelder
Apr 1, 1996·The American Journal of Dermatopathology·H F JordaanD J Rossouw
Jun 26, 2001·Scandinavian Journal of Immunology·S Jeansson, T K Kvien
Jun 2, 2018·Case Reports in Rheumatology·Myat Tun Lin NyoRegan Arendse
Jan 1, 1992·Autoimmunity·R S Bahn, A E Heufelder
Mar 26, 2003·Infection and Immunity·Jennifer L TaylorIan M Orme
Aug 4, 2021·Survey of Ophthalmology·Manish JainJyotirmay Biswas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.