PMID: 15240739Jul 9, 2004Paper

The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501

The Journal of Immunology : Official Journal of the American Association of Immunologists
Nicole Kerlero de RosboA Ben-Nun

Abstract

Autoimmune response to the myelin-associated oligodendrocytic basic protein (MOBP), a CNS-specific myelin constituent, was recently suggested to play a role in the pathogenesis of multiple sclerosis (MS). The pathogenic autoimmune response to MOBP and the associated pathology in the CNS have not yet been fully investigated. In this study, we have characterized the clinical manifestations, pathology, T cell epitope-specificity, and TCRs associated with experimental autoimmune encephalomyelitis (EAE) induced in SJL/J mice with recombinant mouse MOBP (long isoform, 170 aa). Analysis of encephalitogenic MOBP-reactive T cells for reactivity to overlapping MOBP peptides defined MOBP15-36 as their major immunodominant epitope. Accordingly, MOBP15-36 was demonstrated to be the major encephalitogenic MOBP epitope for SJL/J mice, inducing severe/chronic clinical EAE associated with intense perivascular and parenchymal infiltrations, widespread demyelination, axonal loss, and remarkable optic neuritis. Molecular modeling of the interaction of I-A(s) with MOBP15-36, together with analysis of the MOBP15-36-specific T cell response to truncated peptides, suggests MOBP20-28 as the core sequence for I-A(s)-restricted recognition of the encepha...Continue Reading

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Citations

Aug 13, 2009·European Journal of Immunology·Gurumoorthy Krishnamoorthy, Hartmut Wekerle
Mar 26, 2013·CNS Neuroscience & Therapeutics·Shukkur M Farooq, Hossam M Ashour
Aug 20, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liliana E LuccaRoland S Liblau
Aug 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathali KaushanskyAvraham Ben-Nun
Nov 6, 2018·AJNR. American Journal of Neuroradiology·C SaadeF El-Merhi
Jun 12, 2020·Brain Sciences·Catherine KoukoulitsaThomas Mavromoustakos
Mar 7, 2006·Biopolymers·Maria Claudia Alcaro, Anna Maria Papini
Jul 4, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Samantha JilekRenaud A Du Pasquier
Jan 11, 2019·International Journal of Molecular Sciences·Giuseppe CappellanoUmberto Dianzani
Jan 11, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Bernadette Pöllinger
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathali KaushanskyAvraham Ben-Nun

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