The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry

The Journal of Cell Biology
H-Christian von BüdingenJonah R Chan

Abstract

Myelin oligodendrocyte glycoprotein (MOG) is a central nervous system myelin-specific molecule expressed on the outer lamellae of myelin. To date, the exact function of MOG has remained unknown, with MOG knockout mice displaying normal myelin ultrastructure and no apparent specific phenotype. In this paper, we identify nerve growth factor (NGF) as a binding partner for MOG and demonstrate that this interaction is capable of sequestering NGF from TrkA-expressing neurons to modulate axon growth and survival. Deletion of MOG results in aberrant sprouting of nociceptive neurons in the spinal cord. Binding of NGF to MOG may offer widespread implications into mechanisms that underlie pain pathways.

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Citations

Apr 30, 2017·Journal of Alzheimer's Disease : JAD·Junjun SunQingguo Ren
Nov 15, 2018·Frontiers in Neuroanatomy·Bruna Valério-GomesRoberto Lent
May 24, 2017·Frontiers in Immunology·Patrick PeschlMarkus Reindl
Apr 6, 2018·Frontiers in Cellular Neuroscience·Stephen D SkaperPietro Giusti
Dec 29, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Stephen D SkaperPietro Giusti
Apr 7, 2018·Therapeutic Advances in Neurological Disorders·Martin S WeberWolfgang Brück
Dec 19, 2018·Nature Reviews. Neurology·Markus Reindl, Patrick Waters
May 20, 2020·Frontiers in Psychiatry·Danielle Gouvêa-JunqueiraFernanda Crunfli
Sep 26, 2020·Frontiers in Cellular Neuroscience·Olaf JahnHauke B Werner
Sep 7, 2018·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Susanna AsseyerFriedemann Paul
Oct 17, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Amanda MarchionattiDouglas Kazutoshi Sato
Dec 5, 2020·Neurology. Neuroimmunology and Neuroinflammation·Simon RinaldiUNKNOWN Australian and New Zealand MOG Study Group
Oct 24, 2020·Nature Reviews. Disease Primers·Sven JariusBrigitte Wildemann
Aug 31, 2021·Cellular and Molecular Neurobiology·Bhakta Prasad Gaire

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Methods Mentioned

BETA
pull-down
ELISA
pulls down
Coimmunoprecipitation
ELISAs

Software Mentioned

Chimera
MatchMaker
AxioVision

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