The myelinated fiber loss in the corpus callosum of mouse model of schizophrenia induced by MK-801

Journal of Psychiatric Research
Yun XiuYong Tang

Abstract

Previous magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) investigations have shown that the white matter volume and fractional anisotropy (FA) were decreased in schizophrenia (SZ), which indicated impaired white matter integrity in SZ. However, the mechanism underlying these abnormalities has been less studied. The current study was designed to investigate the possible reasons for white matter abnormalities in the mouse model of SZ induced by NMDA receptor antagonist using the unbiased stereological methods and transmission electron microscope technique. We found that the mice treated with MK-801 demonstrated a series of schizophrenia-like behaviors including hyperlocomotor activity and more anxiety. The myelinated fibers in the corpus callosum (CC) of the mice treated with MK-801 were impaired with splitting lamellae of myelin sheaths and segmental demyelination. The CC volume and the total length of the myelinated fibers in the CC of the mice treated with MK-801 were significantly decreased by 9.4% and 16.8% when compared to those of the mice treated with saline. We further found that the loss of the myelinated fibers length was mainly due to the marked loss of the myelinated nerve fibers with the diameter...Continue Reading

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Citations

Jan 25, 2017·The Journal of Comparative Neurology·Yuan GaoYong Tang
Apr 27, 2017·Neurochemical Research·Robert Fern
Oct 8, 2017·Developmental Neurobiology·Erin M GibsonMichelle Monje
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ruhi TurkmenHasan Huseyin Demirel
Jul 21, 2020·Journal of Neuroscience Methods·Surya RajanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 30, 2021·Environmental Science and Pollution Research International·Murat Sırrı AkosmanHasan Hüseyin Demirel

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