PMID: 1201470Nov 1, 1975Paper

The myocardial effects of pancuronium

Canadian Anaesthetists' Society Journal
P C DukeJ Gartner

Abstract

The effect of pancuronium on myocardial contractility was studied in three different animal preparations. Pancuronium produced no change in isometric contraction of rabbit atrial or cat papillary muscle but displaced the acetylcholine dose-response curve to the right in the papillary muscle preparations, verifying a muscarinic blocking effect of this drug. In atropinized dogs in vivo pancuronium produced no significant change in the cardiovascular parameters studied. These studies show that pancuronium exerts its cardiovascular effects primarily by blocking muscarinic receptors in the heart.

References

Apr 1, 1971·British Journal of Anaesthesia·G R Kelman, B R Kennedy
Mar 1, 1974·Canadian Anaesthetists' Society Journal·E K ZsigmondR C Kelsch
Aug 1, 1968·European Journal of Pharmacology·I L BontaF H Derkx

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