The myocardial protective effects of a moderate-potassium adenosine-lidocaine cardioplegia in pediatric cardiac surgery

The Journal of Thoracic and Cardiovascular Surgery
Zhen-xiao JinDinghua Yi

Abstract

We sought to evaluate a moderate-potassium cardioplegic solution using adenosine and lidocaine as the arresting and protecting cardioprotective combination in pediatric cardiac surgery. One hundred thirty-four patients with congenital heart disease were randomly allocated to one of 3 groups according to the cardioplegia formula used: the high-potassium (HP) group (K(+), 20 mmol/L), 46 patients; the high-potassium adenosine-lidocaine (HPAL) group (K(+), 20 mmol/L; adenosine, 0.7 mmol/L; and lidocaine, 0.7 mmol/L), 44 patients; and the moderate-potassium adenosine-lidocaine (MPAL) group (K(+), 10 mmol/L; adenosine, 0.7 mmol/L; and lidocaine, 0.7 mmol/L), 44 patients. Hemodynamic data during the operation and postoperative data were recorded. Serum cardiac troponin I concentrations were examined at the time points of before cardiopulmonary bypass and 1, 3, 6, 12, and 24 hours after aortic crossclamp removal. At the end of cardiopulmonary bypass and modified ultrafiltration, the systolic and pulse pressures of the MPAL group were significantly increased compared with the respective values of the HP group. At the time points of 1 to 12 hours after reperfusion, the levels of serum cardiac troponin I were significantly decreased in th...Continue Reading

References

Jul 27, 1999·The Annals of Thoracic Surgery·A M JayawantR J Damiano
Dec 1, 1999·Current Opinion in Cardiology·D J Chambers
Mar 6, 2004·The Journal of Thoracic and Cardiovascular Surgery·Geoffrey P Dobson, Michael W Jones
Mar 5, 2005·The Journal of Thoracic and Cardiovascular Surgery·Joel S CorveraJakob Vinten-Johansen
May 1, 2007·The Journal of Thoracic and Cardiovascular Surgery·Kathryn L SlootsGeoffrey P Dobson
May 29, 2007·The Annals of Thoracic Surgery·Zhen-Xiao JinDing-Hua Yi

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Citations

Feb 24, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Zhenxiao JinDinghua Yi
Feb 24, 2011·British Journal of Anaesthesia·E-H LeeI-C Choi
May 23, 2014·Integrative and Comparative Biology·Quintin J QuinonesMihai V Podgoreanu
Feb 6, 2010·The Journal of Thoracic and Cardiovascular Surgery·Kathryn L Sloots, Geoffrey P Dobson
Oct 20, 2012·International Journal of Cardiology·Jakob Vinten-Johansen
Jul 12, 2011·The Journal of Thoracic and Cardiovascular Surgery·Donna M Rudd, Geoffrey P Dobson
Apr 7, 2017·The Journal of Trauma and Acute Care Surgery·James A BynumAndrew P Cap
Feb 24, 2016·Perfusion·Geoff Lockwood
Sep 28, 2017·Pediatric Cardiology·Konstantinos S MylonasKonstantinos P Economopoulos
Dec 20, 2015·The Journal of Trauma and Acute Care Surgery·Geoffrey Phillip Dobson, Hayley Louise Letson
Oct 20, 2012·Critical Care Medicine·Robert M Van Haren, Kenneth G Proctor
Nov 10, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alessandra FrancicaFrancesco Onorati

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