The myoneural effects of propofol emulsion (Diprivan) on the nerve-muscle preparations of rats

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
A O Abdel-Zaher, F G Askar

Abstract

The potential effects of propofol emulsion (Diprivan) on the neuromuscular transmission and muscular contraction were studied using in vitro and in vivo nerve-muscle preparations of rats. The contractions of the isolated rat diaphragm elicited by either indirect or direct electrical stimulation were inhibited by propofol emulsion at threshold concentrations of 42 and 112 mumol l-1, respectively. Similarly, the gastrocnemius muscle contractions induced by either indirect or direct electrical stimulation in vivo were inhibited by propofol emulsion administration as a bolus injection of 2.5 mg kg-1 intravenously, followed by intravenous infusion of 150 micrograms kg-1 min-1 for 1 h into rats. The inhibitory effects of propofol in both preparations were greater with indirect rather than direct stimulation. Propofol emulsion was found to be capable of enhancing the paralysis of the indirectly stimulated rat diaphragm in vitro and gastrocnemius muscle in vivo induced by either pipecuronium or succinylcholine. The combination of propofol and pipecuronium led to a synergistic inhibition of the neuromuscular transmission, while the combination of propofol and succinylcholine led to additive inhibition. Pretreatment with propofol emulsio...Continue Reading

Citations

Nov 30, 2010·Acta Pharmacologica Sinica·Luciana Ferreira LeiteCristina Guatimosim
Jun 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C ChevalleyM Licker
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