The Mystery behind the Pineal Gland: Melatonin Affects the Metabolism of Cholesterol

Oxidative Medicine and Cellular Longevity
Kamil Karolczak, Cezary Watala

Abstract

Melatonin may be considered a cardioprotective agent. Since atherogenesis is partly associated with the metabolism of lipoproteins, it seems plausible that melatonin affects cardiovascular risk by modulating the metabolism of cholesterol and its subfractions. Moreover, cholesterol-driven atherogenesis can be hypothetically reduced by melatonin, mainly due to the minimalization of harmful reactions triggered in the cardiovascular system by the reactive oxygen species-induced toxic derivatives of cholesterol. In this review, we attempted to summarize the available data on the hypolipemizing effects of melatonin, with some emphasis on the molecular mechanisms underlying these reactions. We aimed to attract readers' attention to the numerous gaps of knowledge present in the reviewed field and the essential irrelevance between the findings originating from different sources: clinical observations and in vitro mechanistic and molecular studies, as well as preclinical experiments involving animal models. Overall, such inconsistencies make it currently impossible to give a reliable opinion on the action of melatonin on the metabolism of lipoproteins.

References

Jan 11, 1991·The American Journal of Physiology·K A PritchardM B Stemerman
Dec 1, 1990·Biochemical Society Transactions·F PlaneM Jacobs
Jan 1, 1990·The American Journal of Physiology·M TakahashiC Kawai
Aug 1, 1995·Endocrine Research·T Y Chan, P L Tang
Aug 30, 1994·Biochemical and Biophysical Research Communications·D Müller-WielandW Krone
Jan 1, 1993·Life Sciences·G Benítez-KingF Antón-Tay
Feb 1, 1996·The Journal of Clinical Investigation·E Ehrenwald, P L Fox
May 15, 1996·Biochemical and Biophysical Research Communications·C PieriS Damjanovich
Sep 20, 1997·British Journal of Clinical Pharmacology·H SeegarT H Lippert
Feb 24, 1999·Journal of Cardiovascular Pharmacology·B BucherM Masson-Pévet
Jul 29, 1999·American Journal of Therapeutics·J P Rindone, R Achacoso
Sep 3, 1999·The Journal of Biological Chemistry·G M ChisolmM K Cathcart
Jul 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·A C CarrB Frei
Mar 7, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Antonella SaijaFrancesco Castelli
Aug 3, 2002·Journal of Pineal Research·Dominique Bonnefont-RousselotMonique Gardès-Albert
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·Monica I MasanaDiana N Krause
Nov 19, 2002·FEBS Letters·M ExnerB Gmeiner
Aug 19, 2003·Trends in Cardiovascular Medicine·Chieko Mineo, Philip W Shaul
Jul 5, 2005·Trends in Pharmacological Sciences·Jean A BoutinPhilippe Delagrange
Sep 5, 2006·Journal of Pineal Research·Eduardo K TamuraRegina P Markus
Mar 14, 2007·Journal of Pineal Research·Saad Abdul-Rehman Hussain
Jun 29, 2007·European Journal of Pharmacology·Elena Ju SudnikovichIlya B Zavodnik
Aug 28, 2007·European Journal of Pharmacology·Perumal SubramanianD P Cardinali
Sep 7, 2007·Journal of Pineal Research·Vânia Rodrigues de LimaTânia Beatriz Creczynski-Pasa
Mar 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Hong Wang, Robert H Eckel
Jul 29, 2009·PPAR Research·Tiangang Li, John Y L Chiang
Jul 1, 2010·Journal of Pineal Research·Vânia R de LimaTânia B Creczynski-Pasa
Nov 23, 2010·Journal of Pineal Research·Ahmad AgilGumersindo Fernández Vázquez
May 30, 2013·Biochimica Et Biophysica Acta·E DrolleZ Leonenko

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Citations

Jan 17, 2021·Bulletin of Experimental Biology and Medicine·I V BaishnikovaI A Vinogradova
Mar 24, 2021·Experimental Gerontology·Hongfu JinYusheng Li

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