PMID: 7580668Oct 21, 1995Paper

The myth of maternal transmission of spongiform encephalopathy

BMJ : British Medical Journal
R M Ridley, H F Baker

Abstract

It has long been accepted that the pattern of occurrence of scrapie--the form of spongiform encephalopathy associated with sheep--is determined mainly by maternal transmission, and this view has had a profound influence on policy decisions in the control of bovine spongiform encephalopathy and on public concern over the risk to human health form this disease. The occurrence of maternal transmission is, however, not predicted by modern knowledge of the aetiology of spongiform encephalopathy, and even though claims of maternal transmission have been reiterated frequently in the literature, re-examination of the source data reveals that these data are extremely scanty, unreplicated, and probably subject to ascertainment bias. The probability of maternal transmission of spongiform encephalopathy in any species should be viewed with the greatest scepticism.

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Citations

Jan 1, 1996·Brain Research Bulletin·H F Baker, R M Ridley
Apr 30, 1998·Journal of the Neurological Sciences·R A Shakir
Sep 6, 2001·Preventive Veterinary Medicine·P HoppJ Jarp
May 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C MacKnight
May 29, 2008·The Journal of Infectious Diseases·Jiri G SafarStanley B Prusiner
Jul 31, 1999·The Veterinary Quarterly·R M Ridley, H F Baker
Dec 1, 2009·Preventive Veterinary Medicine·Linda J HoinvilleJohn W Wilesmith
Oct 26, 1999·Medical Hypotheses·M Füzi
Nov 1, 1996·Australian Veterinary Journal·I M Parsonson
Mar 29, 2001·The Journal of Biological Chemistry·W TuoK I O'Rourke
Oct 3, 2003·British Medical Bulletin·Nora Hunter
Nov 7, 1996·Nature·R M Ridley, H F Baker
May 14, 2005·Journal of Animal Science·J NovakofskiR H McCusker
Oct 1, 1996·Journal of the Royal Society of Health

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