The n-3 and n-6 polyunsaturated fatty acid composition of plasma phospholipids in pregnant women and their infants. relationship with maternal linoleic acid intake

Clinical Chemistry and Laboratory Medicine : CCLM
Patrick Rum, Gerard Hornstra

Abstract

The availability of long-chain polyunsaturated fatty acids during infancy has been related to neonatal growth and development. Fatty acid concentration at birth is an important predictor of postnatal level. The primary aim of this study was to provide a description of the distribution of n-3 and n-6 polyunsaturated fatty acids in the plasma phospholipid fraction of pregnant women remaining on a Western-style diet and their neonates. The plasma phospholipid polyunsaturated fatty acid composition was determined by gas-liquid chromatography in 889 mother-infant pairs. Blood samples were taken during the first, second and third trimester of pregnancy, at delivery, and from the umbilical vein at birth. Mean (+/- SD) fatty acid concentrations are reported in mg/l and as percentage of total fatty acids (% wt/wt). In addition, the 10th, 25th, 50th, 75th and 90th percentiles are given. The distribution of docosahexaenoic acid (22:6n-3) and arachidonic acid (20:4n-6) concentrations in umbilical plasma phospholipids is also reported as a function of gestational age and maternal linoleic acid intake during pregnancy. This data can be be used as a reference for future studies and may aid in identifying term infants with a relatively low lon...Continue Reading

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Citations

May 16, 2012·European Journal of Nutrition·Kristina Warstedt, Karel Duchén
Jan 29, 2009·The British Journal of Nutrition·Chantal E H DirixGerard Hornstra
Jan 31, 2006·The British Journal of Nutrition·Pablo SanjurjoJuan Rodríguez-Soriano
Mar 17, 2011·Lipids·Roseli de Souza Santos da CostaMaria da Graças Tavares do Carmo
Jan 28, 2014·European Journal of Nutrition·Wolfgang BernhardAxel R Franz
Aug 1, 2009·Medical Hypotheses·Christopher J Pavlovski
Apr 22, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S M A DonahueE Oken
Jun 28, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sylvia H J JochemsMaurice P Zeegers
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Nov 11, 2011·The American Journal of Clinical Nutrition·Gabriele KohlboeckUNKNOWN LISAplus Study Group
Aug 24, 2004·The American Journal of Clinical Nutrition·Sheila M InnisD Janette King

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