The n-Butanol Fraction and Rutin from Tartary Buckwheat Improve Cognition and Memory in an In Vivo Model of Amyloid-β-Induced Alzheimer's Disease

Journal of Medicinal Food
Ji Yeon ChoiSanghyun Lee

Abstract

This study examined the beneficial effects of the n-butanol fraction and rutin extracted from tartary buckwheat (TB) on learning and memory deficits in a mouse model of amyloid β (Aβ)-induced Alzheimer's disease (AD). Learning and memory were assessed using the T-maze, object recognition, and Morris water maze tests. Animals administered Aβ showed impaired cognition and memory, which were alleviated by oral administration of an n-butanol fraction and rutin extracted from TB. Similarly, Aβ-induced increases in nitric oxide formation and lipid peroxidation in the brain, liver, and kidneys were attenuated by treatment with n-butanol fraction and rutin from TB in addition to antioxidant effects observed in control (nonAβ-treated) animals. The results of the present study suggest that the n-butanol fraction and rutin extracted from TB are protective against and have possible therapeutic applications for the treatment of AD.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Nov 15, 1978·The Biochemical Journal·R M McMillanJ L Gordon
Dec 1, 1986·Journal of Pharmacological Methods·S E Laursen, J K Belknap
May 1, 1984·Journal of Neuroscience Methods·R Morris
Apr 1, 1995·Trends in Neurosciences·M A SmithG Perry
Oct 19, 1999·Brain Research. Brain Research Reviews·F TorreillesJ Torreilles
Dec 10, 1999·Journal of Agricultural and Food Chemistry·D Dietrych-Szostak, W Oleszek
Nov 18, 2000·European Journal of Clinical Nutrition·S P BoyleA R Collins
Mar 21, 2001·Biological & Pharmaceutical Bulletin·T MukodaA Ishiguro
Dec 1, 2001·Free Radical Biology & Medicine·J Nordberg, E S Arnér
Feb 13, 2002·Methods and Findings in Experimental and Clinical Pharmacology·W RenZ Wang
Feb 5, 2003·Neuro-Signals·Xiongwei ZhuMark A Smith
Sep 6, 2003·Free Radical Biology & Medicine·Igor RebrinRajindar S Sohal
Oct 16, 2003·Journal of Agricultural and Food Chemistry·Nina FabjanIvan Kreft
Dec 4, 2003·Journal of Agricultural and Food Chemistry·Julianne M KawaRoman Przybylski
Jun 1, 1952·Journal of Comparative and Physiological Psychology·K C MONTGOMERY
Feb 27, 2004·Physiology & Behavior·Mikhail Yu StepanichevNatalia V Gulyaeva
Aug 12, 2004·Phytotherapy Research : PTR·Ganesh Chandra JagetiaKiran S Babu
Dec 21, 2004·Nature Neuroscience·James P ClearyKaren H Ashe
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kavon Rezai-ZadehJun Tan
Nov 2, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jun WangGiulio Maria Pasinetti
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Mar 24, 2007·Phytotherapy Research : PTR·Neelima B Chauhan, Jimena Sandoval
Jul 16, 2008·The Journal of Pharmacology and Experimental Therapeutics·Tursun AlkamToshitaka Nabeshima
Dec 5, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vanessa VillardTangui Maurice
Jul 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shiyong PengMargaret Fahnestock
Feb 4, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·P A OmololuI J Kade

❮ Previous
Next ❯

Citations

Apr 6, 2016·Nutrition Research Reviews·Marko Kreft
Aug 14, 2015·Journal of Agricultural and Food Chemistry·Juan Antonio Giménez-Bastida, Henryk Zieliński
Dec 7, 2016·Journal of Zhejiang University. Science. B·Tao BaoChong-de Sun
Oct 4, 2017·Current Medicinal Chemistry·Barbara BudzynskaSeyed Mohammad Nabavi
May 1, 2020·Breeding Science·Tatsuro SuzukiAndrea Brunori
Feb 26, 2019·Oxidative Medicine and Cellular Longevity·Rongzi LiJeganathan Ramesh Babu
Jul 28, 2018·Oxidative Medicine and Cellular Longevity·Adaze Bijou EnogieruOkobi Eko Ekpo
Nov 23, 2016·International Journal of Biological Macromolecules·Sandipan Chakraborty, Soumalee Basu
Mar 9, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Fahsai KantawongYoung-Tae Chang

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Ji Yeon ChoiSanghyun Lee
Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Rui YangXuewen Liu
© 2021 Meta ULC. All rights reserved