The N-methyl-D-aspartate receptor channel complex and the sigma site have different target sizes.

European Journal of Pharmacology
E H Wong, M Nielsen

Abstract

Radiation inactivation technique has been used to measure the molecular sizes of the N-methyl-D-aspartate (NMDA) receptor and the sigma recognition site. Target size analysis of [3H]MK-801 (dizocilpine maleate) binding to the NMDA receptor channel complex in rat cortical membranes has given a molecular size of 128,000 +/- 9,000 Da. This is in contrast to the target size of the sigma site in the same tissue as labelled by [3H]DTG (ditolylguanidine), giving a value of 36,000 +/- 2,900 Da. These studies have provided evidence for a clear difference in the molecular sizes of these two recognition sites.

References

Aug 15, 1989·European Journal of Pharmacology·T HonoréM Nielsen
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E WeberJ F Keana
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E H WongL L Iversen
Jan 27, 1984·Neuroscience Letters·S C LummisJ C Ellory

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