PMID: 14550530Oct 11, 2003Paper

The N-terminal and transmembrane domains of Commissureless are necessary for its function and trafficking within neurons

Mechanisms of Development
Marios Georgiou, Guy Tear

Abstract

Commissureless (Comm) is a novel transmembrane molecule necessary both for commissural axons to cross the midline of the Drosophila central nervous system and normal synaptogenesis. Comm is able to reduce cell surface levels of Roundabout (Robo), a receptor for the midline repellent Slit, on commissural axons and unknown inhibitors of synaptogenesis expressed on muscle cells. Comm is expressed dynamically and is found at the cell surface and within intracellular vesicles. Comm can bind Robo and when the proteins are co-expressed Robo is found co-localised with Comm intracellularly. Here we show that the ability of Comm to localise intracellularly and hence regulate Robo surface levels requires sequences in both the N-terminal and transmembrane domains. We also show that Comm can dimerise via its N-terminal domain. Furthermore, absence of the Comm N-terminal and transmembrane regions results in the protein being restricted to the neuron soma.

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Citations

Jan 20, 2005·Nature Neuroscience·Krystyna KelemanBarry J Dickson
Oct 13, 2006·Annual Review of Cell and Developmental Biology·Barry J Dickson, Giorgio F Gilestro
May 4, 2011·Cellular and Molecular Life Sciences : CMLS·Homaira Nawabi, Valérie Castellani
Sep 1, 2016·Development·Heike Blockus, Alain Chédotal

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