The NADPH-Dependent Thioredoxin Reductase C-2-Cys Peroxiredoxin Redox System Modulates the Activity of Thioredoxin x in Arabidopsis Chloroplasts

Plant & Cell Physiology
Valle OjedaFrancisco Javier Cejudo

Abstract

The chloroplast redox network is composed of a complex set of thioredoxins (Trxs), reduced by ferredoxin (Fdx) via a Fdx-dependent Trx reductase (FTR), and an NADPH-dependent Trx reductase with a joint Trx domain, NTRC, which efficiently reduces 2-Cys peroxiredoxins (2-Cys Prxs). Recently, it was proposed that the redox balance of 2-Cys Prxs maintains the redox state of f-type Trxs, thus allowing the proper redox regulation of Calvin-Benson cycle enzymes such as fructose 1,6-bisphosphatase (FBPase). Here, we have addressed whether the action of 2-Cys Prxs is also exerted on Trx x. To that end, an Arabidopsis thaliana quadruple mutant, ntrc-trxx-Δ2cp, which is knocked out for NTRC and Trx x, and contains severely decreased levels of 2-Cys Prxs, was generated. In contrast to ntrc-trxx, which showed a severe growth inhibition phenotype and poor photosynthetic performance, the ntrc-trxx-Δ2cp mutant showed a significant recovery of growth rate and photosynthetic efficiency, indicating that the content of 2-Cys Prxs is critical for the performance of plants lacking both NTRC and Trx x. Light-dependent reduction of FBPase was severely impaired in mutant plants lacking NTRC or NTRC plus Trx x, despite the fact that neither NTRC nor Trx...Continue Reading

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Citations

Nov 30, 2018·Antioxidants·James D WestMatthew A Loberg
Apr 17, 2019·The Biochemical Journal·Lauri Nikkanen, Eevi Rintamäki
Apr 26, 2019·Frontiers in Plant Science·Francisco Javier CejudoJuan Manuel Pérez-Ruiz
Oct 18, 2020·Biological Chemistry·Daniel WittmannBernhard Grimm
Jan 27, 2021·International Journal of Molecular Sciences·Antonio Sánchez-GuerreroFrancisca Sevilla
Apr 2, 2021·Plant Physiology·Francisco Javier CejudoJuan Manuel Pérez-Ruiz
May 12, 2021·Journal of Experimental Botany·Valeria A DmitrievaOlga V Voitsekhovskaja

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