The NADPH Oxidase and Microbial Killing by Neutrophils, With a Particular Emphasis on the Proposed Antimicrobial Role of Myeloperoxidase within the Phagocytic Vacuole

Microbiology Spectrum
Adam P Levine, Anthony W Segal

Abstract

This review is devoted to a consideration of the way in which the NADPH oxidase of neutrophils, NOX2, functions to enable the efficient killing of bacteria and fungi. It includes a critical examination of the current dogma that its primary purpose is the generation of hydrogen peroxide as substrate for myeloperoxidase-catalyzed generation of hypochlorite. Instead, it is demonstrated that NADPH oxidase functions to optimize the ionic and pH conditions within the vacuole for the solubilization and optimal activity of the proteins released into this compartment from the cytoplasmic granules, which kill and digest the microbes. The general role of other NOX systems as electrochemical generators to alter the pH and ionic composition in compartments on either side of a membrane in plants and animals will also be examined.

References

May 10, 2019·F1000Research·Alice E JasperGeorgia M Walton
Sep 12, 2017·Frontiers in Cellular and Infection Microbiology·Giang T NguyenJoan Mecsas
Mar 16, 2017·Frontiers in Pharmacology·Juliet R FooteAnthony W Segal
May 17, 2017·Frontiers in Cellular and Infection Microbiology·Roger D Pechous
May 11, 2018·Mucosal Immunology·Gabriella Aviello, Ulla G Knaus

Related Concepts

Neutrophil Band Cells
Hydrogen Peroxide
Virus Viability
Body Fluid Compartments
Membrane
Filamentous fungus
Neutrophils as Percentage of Blood Leukocytes (Lab Test)
Peroxidase Activity
NADPH Oxidase
Ion Channel

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