The NAFLD-MAFLD debate: Eminence vs evidence.

Liver International : Official Journal of the International Association for the Study of the Liver
Yasser FouadDina Attia

Abstract

Debates are inevitable in science and could be a powerful tool for addressing controversial topics as it promotes critical thinking and inspires individuals to consider alternate viewpoints. However, debates can help only to identify the issues that need to be clarified to address this question, but it can never help resolve the controversy itself. In the era of evidence-based medicine, the need for an evidence-based debate is mandatory. Polarising opinions and major debate have recently arisen in hepatology on the nomenclature and diagnostic criteria for fatty liver disease associated with metabolic dysfunction (non alcoholic fatty liver disease [NAFLD]-metabolic (dysfunction) associated fatty liver disease [MAFLD] debate). The aim of this viewpoint is to suggest a way to settle the debate through evidence. Descriptive review using PubMed to identify literature on the evidence and eminence-based medicine and studies comparing MAFLD and NAFLD criteria. The emerging studies comparing the performance of diagnostic criteria of NAFLD and MAFLD represent the dawn of a new era for reframing the ongoing debate by acquisition of the mandatory evidence that will both resolve the debate and lead to novel avenues of research. In conclusio...Continue Reading

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Citations

Dec 4, 2020·Expert Review of Gastroenterology & Hepatology·Yusuf YilmazGiovanni Musso
Feb 16, 2021·Journal of Hepatology·Mohammed Eslam, Jacob George
Dec 7, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Fernando Sierra, Andrés Cárdenas
Jan 17, 2021·Journal of Hepatology·Mohammed EslamJacob George
Jan 27, 2021·Journal of Hepatology·Shereen Abdel AlemYasser Fouad
Feb 22, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jacob GeorgeAndreas Geier
Mar 23, 2021·JHEP Reports : Innovation in Hepatology·Shuna MyersNicolas Goossens
Apr 4, 2021·Children·Anna Di SessaPierluigi Marzuillo
May 19, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Alessandro Mantovani, Luca Valenti
Jun 11, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alessandro Mantovani
Jul 9, 2021·Cellular & Molecular Biology Letters·Jianan ZhaoJinghua Peng
Aug 9, 2021·The Lancet. Gastroenterology & Hepatology·Mohammed EslamJacob George

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